{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T22:09:53Z","timestamp":1747174193040,"version":"3.40.5"},"reference-count":42,"publisher":"IMR Press","issue":"3-4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal for Vitamin and Nutrition Research"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:p> Abstract. Background: Endothelial dysfunction (ED) plays a key role in the development and progression of microvascular and macrovascular complications in pediatrics with type 1 diabetes mellitus (T1DM). Coenzyme Q10 (CoQ10) is a nutraceutical with a known anti-inflammatory and anti-oxidant activity. This study was conducted to evaluate the potential effect of CoQ10 on ED and various metabolic parameters. Methods: This prospective randomized open-label pilot study was conducted on 49 T1DM pediatric patients. Seven healthy non-diabetic pediatric subjects who didn\u2019t receive treatment were included as a control group. Eligible patients were randomly allocated into either group I (n\u00a0=\u00a025); received 100\u00a0mg of CoQ10 in addition to standard treatment or group II (n\u00a0=\u00a024); received standard treatment only. The levels of; soluble intracellular adhesion molecule-1 (sICAM-1), glycated hemoglobin (HbA1c), fasting blood glucose (FBG), lipid profile, serum creatinine and liver function tests were assessed for both groups at baseline and after 3 months of treatment. Results: At baseline, compared to an age-matched healthy control group sICAM-1 levels were significantly elevated in group II diabetic patients (276.5 (231.6\u2013320.66) vs 221.8 (177.9\u2013267.1\u00a0ng\/ml), p\u00a0=\u00a00.042. After 3 months of treatment no significant difference was observed in sICAM-1, HbA1c, FBG, lipid profile, serum creatinine and liver function tests between the two study groups. A positive correlation was found between sICAM-1 and HbA1c throughout the study (r\u00a0=\u00a00.308, p\u00a0=\u00a00.0054). Conclusion: Administration of CoQ10 for 3 months in T1DM pediatric patients was well tolerated but had no favorable effect on ED or metabolic parameters. <\/jats:p>","DOI":"10.1024\/0300-9831\/a000636","type":"journal-article","created":{"date-parts":[[2020,1,16]],"date-time":"2020-01-16T10:53:24Z","timestamp":1579172004000},"page":"315-324","source":"Crossref","is-referenced-by-count":10,"title":["Coenzyme Q10 administration has no effect on sICAM-1 and metabolic \t\t\t\t\tparameters of pediatrics with type 1 diabetes mellitus"],"prefix":"10.31083","volume":"91","author":[{"given":"Heba","family":"Serag","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacy, Faculty of Pharmacy \t\t\t\t\tAin Shams University, Cairo, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0250-1709","authenticated-orcid":true,"given":"Lamia","family":"El Wakeel","sequence":"additional","affiliation":[{"name":"Department of Clinical 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