{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T07:01:34Z","timestamp":1763535694370},"reference-count":41,"publisher":"IMR Press","issue":"5-6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal for Vitamin and Nutrition Research"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:p> Abstract. Background\/Aims: Trials on the effects of cholecalciferol supplementation in type 2 diabetes with chronic kidney disease patients were underexplored. Therefore, the aim of this study was to investigate the effects of two different doses of vitamin D supplementation on serum 25-hydroxyvitamin D [25(OH)D] concentrations and metabolic parameters in vitamin D-deficient Korean diabetes patients with chronic kidney disease. Methods: 92 patients completed this study: the placebo group (A, n\u00a0=\u00a033), the oral cholecalciferol 1,000\u00a0IU\/day group (B, n\u00a0=\u00a034), or the single 200,000\u00a0IU injection group (C, n\u00a0=\u00a025, equivalent to 2,000\u00a0IU\/day). 52% of the patients had less than 60 mL\/min\/1.73m<jats:sup>2<\/jats:sup> of glomerular filtration rates. Laboratory test and pulse wave velocity were performed before and after supplementation. Results: After 12 weeks, serum 25(OH)D concentrations of the patients who received vitamin D supplementation were significantly increased (A, -2.4\u00a0\u00b1\u00a01.2\u00a0ng\/mL vs. B, 10.7\u00a0\u00b1\u00a01.2\u00a0ng\/mL vs. C, 14.6\u00a0\u00b1\u00a01.7\u00a0ng\/mL; p\u00a0&lt;\u00a00.001). In addition, the lipid profiles in the vitamin D injection group (C) showed a significant decrease in triglyceride and a rise in HDL cholesterol. However, the other parameters showed no differences. Conclusions: Our data indicated that two different doses and routes of vitamin D administration significantly and safely increased serum 25(OH)D concentrations in vitamin D-deficient diabetes patients with comorbid chronic kidney disease. In the group that received the higher vitamin D dose, the lipid profiles showed significant improvement, but there were no beneficial effects on other metabolic parameters. <\/jats:p>","DOI":"10.1024\/0300-9831\/a000642","type":"journal-article","created":{"date-parts":[[2020,3,9]],"date-time":"2020-03-09T15:48:20Z","timestamp":1583768900000},"page":"649-658","source":"Crossref","is-referenced-by-count":2,"title":["No effect of vitamin D supplementation on metabolic parameters but on \t\t\t\t\tlipids in patients with type 2 diabetes and chronic kidney \t\t\t\t\tdisease"],"prefix":"10.31083","volume":"91","author":[{"given":"Jiwoon","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Yongin Severance \t\t\t\t\tHospital, Yonsei University College of Medicine, Yongin, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji Sun","family":"Nam","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Gangnam 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