{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,10]],"date-time":"2024-08-10T00:08:04Z","timestamp":1723248484322},"reference-count":38,"publisher":"IMR Press","issue":"3-4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal for Vitamin and Nutrition Research"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:p> Abstract. The effects of an adequate supply of vitamin A and iron, in comparison with diets low or absent in vitamin A and low in iron, on the mRNA expression of some biomarkers of iron homeostasis as hepcidin ( Hamp), transferrin receptor-1 ( Tfrc), iron regulatory protein-2 ( Ireb2) and ferritin ( Fth1) in rats were investigated. 35 male Wistar rats were randomly divided into 5 dietary groups: control, sufficient in iron and insufficient in vitamin A (FesvAi), sufficient in iron and depleted in vitamin A (FesvAd), insufficient in iron and sufficient in vitamin A (FeivAs) and insufficient in both iron and vitamin A (FeivAi). After 6 weeks rats showed no significant effects of variations in vitamin A on the expression of Hamp relative to the control group (FesvAi: 1.37-fold; FesvAd: 1.22-fold); however, iron deficiency showed significant reduction on it relative to the control group (FeivAs: 71.4-fold, P\u00a0=\u00a00.0004; FeivAi: 16.1-fold, P\u00a0=\u00a00.0008). Vitamin A deficiency (FesvAd) affects expression of Fth1 independent of low dietary iron in spleen (0.29-fold, P\u00a0=\u00a00.002) and duodenum (5.15-fold, P\u00a0=\u00a00.02). Variations of dietary iron and vitamin A showed significant effects relative to the control group for expression of Tfrc in spleen (FesvAd: 0.18-fold, P\u00a0=\u00a00.01; FeivAs: 0.24-fold, P\u00a0&lt;\u00a00.0001; FeivAi: 0.42-fold, P\u00a0=\u00a00.014), Ireb2 in spleen (FeivAs: 3.7-fold, P\u00a0&lt;\u00a00.0001; FeivAi: 2.9-fold, P\u00a0&lt;\u00a00.0001) and Ireb2 in duodenum (FeivAs: 2.68-fold, P\u00a0=\u00a00.012; FeivAi: 2.60-fold, P\u00a0=\u00a00.014). These results show that vitamin A and iron must be supplied together to regulate some of the main biomarkers of iron metabolism as a strategy to reduce prevalence of iron deficiency anemia. <\/jats:p>","DOI":"10.1024\/0300-9831\/a000666","type":"journal-article","created":{"date-parts":[[2020,7,16]],"date-time":"2020-07-16T14:26:35Z","timestamp":1594909595000},"page":"223-230","source":"Crossref","is-referenced-by-count":1,"title":["Vitamin A does not influence mRNA expression of hormone hepcidin but other biomarkers of iron homeostasis in young male Wistar rats"],"prefix":"10.31083","volume":"92","author":[{"given":"Mauricio","family":"Restrepo-Gallego","sequence":"first","affiliation":[{"name":"Doctorate Program in Bioscience, La Sabana University, Campus Puente del Com\u00fan, Km. 7, Autopista Norte, Bogot\u00e1, Ch\u00eda, Cundinamarca, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis E.","family":"D\u00edaz","sequence":"additional","affiliation":[{"name":"Doctorate Program in Bioscience, La Sabana University, Campus Puente del Com\u00fan, Km. 7, Autopista Norte, Bogot\u00e1, Ch\u00eda, Cundinamarca, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"16242","reference":[{"key":"c1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0067860"},{"volume-title":"Health in 2015: From MDGs, Millennium Development Goals to SDGs, Sustainable Development Goals","year":"2015","author":"World Health Organization","key":"c2"},{"volume-title":"The global prevalence of anaemia in 2011","year":"2015","author":"World Health Organization","key":"c3"},{"key":"c4","doi-asserted-by":"publisher","DOI":"10.1177\/15648265030244S204"},{"volume-title":"Global prevalence of vitamin A deficiency in populations at risk 1995\u20132005: WHO global database on vitamin A deficiency","year":"2009","author":"World Health Organization","key":"c5"},{"key":"c6","doi-asserted-by":"publisher","DOI":"10.1024\/0300-9831.75.6.375"},{"key":"c7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtemb.2012.03.015"},{"key":"c8","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2017.08.008"},{"key":"c9","doi-asserted-by":"publisher","DOI":"10.1016\/j.paed.2017.08.004"},{"key":"c10","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcna.2016.09.003"},{"key":"c11","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2008.03.008"},{"key":"c12","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2011.02.014"},{"key":"c13","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2011.048926"},{"key":"c14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2014.05.005"},{"key":"c15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jped.2014.03.003"},{"key":"c16","doi-asserted-by":"publisher","DOI":"10.3390\/nu9070671"},{"key":"c17","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2018.1427552"},{"key":"c18","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2008.11.030"},{"key":"c19","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-012-9397-6"},{"key":"c20","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/127.5.838S"},{"key":"c21","doi-asserted-by":"publisher","DOI":"10.4103\/0976-500X.119726"},{"key":"c22","doi-asserted-by":"publisher","DOI":"10.1590\/S0102-311X2007000600016"},{"key":"c23","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2019.01.016"},{"issue":"3","key":"c24","first-page":"413","volume":"23","author":"Kumar MV","year":"2014","journal-title":"Asia Pac J Clin Nutr"},{"key":"c25","doi-asserted-by":"publisher","DOI":"10.1017\/S1368980016003608"},{"key":"c26","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.2008.00018.x"},{"key":"c27","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0409808102"},{"key":"c28","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2009.12.030"},{"key":"c29","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2013.11.004"},{"key":"c30","doi-asserted-by":"publisher","DOI":"10.1109\/HHBE.2011.6027917"},{"key":"c31","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2011.08.015"},{"key":"c32","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2014.00176"},{"key":"c33","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw419"},{"key":"c34","doi-asserted-by":"publisher","DOI":"10.1186\/s12263-016-0519-4"},{"key":"c35","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-014-0051-3"},{"key":"c36","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v23.i41.7347"},{"key":"c37","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-011-1152-3"},{"issue":"3","key":"c38","first-page":"G482","volume":"291","author":"Sheikh N","year":"2006","journal-title":"Am J Physiol Liver Physiol"}],"container-title":["International Journal for Vitamin and Nutrition Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/econtent.hogrefe.com\/doi\/pdf\/10.1024\/0300-9831\/a000666","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T02:06:29Z","timestamp":1723169189000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.imrpress.com\/journal\/IJVNR\/92\/3-4\/10.1024\/0300-9831\/a000666"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":38,"journal-issue":{"issue":"3-4","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["10.1024\/0300-9831\/a000666"],"URL":"https:\/\/doi.org\/10.1024\/0300-9831\/a000666","relation":{},"ISSN":["0300-9831","1664-2821"],"issn-type":[{"type":"print","value":"0300-9831"},{"type":"electronic","value":"1664-2821"}],"subject":[],"published":{"date-parts":[[2022,7]]}}}