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A significant HbA<jats:sub>1c<\/jats:sub> decrease was observed in Vitamin D3 (from 7.6% or 60\u00a0mmol\/mol to 7.1% or 54\u00a0mmol) at 6 months compared to baseline, and to placebo (p\u00a0&lt;\u00a00.05 for both). At the end of the study period, we noticed a change in the amount in doses of oral or subcutaneous hypoglycemic agents and insulin, respectively. The use of metformin, acarbose, and pioglitazone was significantly lower (p\u00a0=\u00a00.037, p\u00a0=\u00a00.048, and p\u00a0=\u00a00.042, respectively) than at the beginning of the study in the Vitamin D3 therapy group. The units of Lispro, Aspart, and Glargine insulin were lower in the Vitamin D3 group at the end of the study (p\u00a0=\u00a00.031, p\u00a0=\u00a00.037, and p\u00a0=\u00a00.035, respectively) than in the placebo group. Conclusions: in type 2 diabetic patients with Vitamin D deficiency, the restoration of value in the Vitamin D standard has led not only to an improvement in the glyco-metabolic compensation, but also to a reduced posology of some oral hypoglycemic agents and some types of insulin used. <\/jats:p>","DOI":"10.1024\/0300-9831\/a000673","type":"journal-article","created":{"date-parts":[[2020,8,14]],"date-time":"2020-08-14T13:18:33Z","timestamp":1597411113000},"page":"91-100","source":"Crossref","is-referenced-by-count":11,"title":["Vitamin D3 supplementation improves glycemic control in type 2 diabetic patients: Results from an Italian clinical trial"],"prefix":"10.31083","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3573-4760","authenticated-orcid":true,"given":"Giuseppe","family":"Derosa","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy"},{"name":"Laboratory of Molecular Medicine, University of Pavia, Pavia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"D\u2019Angelo","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Medicine, University of Pavia, Pavia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Martinotti","sequence":"additional","affiliation":[{"name":"S.A.V.E. 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