{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T09:47:07Z","timestamp":1773395227502,"version":"3.50.1"},"reference-count":36,"publisher":"IMR Press","issue":"3-4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal for Vitamin and Nutrition Research"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:p> Abstract. This study investigates lycopene\u2019s preventive efficacy in skeletal muscle ischemia-reperfusion (I\/R) induced lung injury. Thirty-two rats were randomly assigned to control group, lycopene group, I\/R group and I\/R\u00a0+\u00a0lycopene group. In the lycopene and I\/R\u00a0+\u00a0lycopene groups, the rats initially received 10\u00a0mg\/kg\/day lycopene orally for 15 days. Then, dissection around the abdominal aorta was performed in all rats under general anesthesia. The aorta was clamped at the infrarenal level in the I\/R group and I\/R\u00a0+\u00a0lycopene group for two hours before two hours of reperfusion. The mean serum levels of malondialdehyde (53.0\u00a0\u00b1\u00a020.14\u00a0nmol\/mL) and superoxide dismutase (1.03\u00a0\u00b1\u00a00.16\u00a0U\/mL) were higher and lower in the I\/R group than the other three groups, respectively (p\u00a0&lt;\u00a00.001). The mean serum IMA level of I\/R\u00a0+\u00a0lycopene group (0.42\u00a0\u00b1\u00a00.04 abs\/u) was lower than the I\/R group (0.47\u00a0\u00b1\u00a00.04 abs\/u) (p\u00a0=\u00a00.015). The mean tissue malondialdehyde levels of I\/R group (69.10\u00a0\u00b1\u00a011.55\u00a0nmol\/mL) and I\/R\u00a0+\u00a0lycopene group (68.36\u00a0\u00b1\u00a021.17\u00a0nmol\/mL) were high compared to the control group (49.87\u00a0\u00b1\u00a06.52\u00a0nmol\/mL) and lycopene group (47.82\u00a0\u00b1\u00a04.44\u00a0nmol\/mL) (p\u00a0=\u00a00.002). The mean tissue glutathione peroxidase (p\u00a0&lt;\u00a00.001) and superoxide dismutase (p\u00a0=\u00a00.001) levels of I\/R group (121.81\u00a0\u00b1\u00a043.59\u00a0nmol\/mL and 25.17\u00a0\u00b1\u00a08.69\u00a0U\/mL) were low compared to the control group (236.12\u00a0\u00b1\u00a018.01\u00a0nmol\/mL and 46.30\u00a0\u00b1\u00a05.17\u00a0U\/mL), lycopene group (227.52\u00a0\u00b1\u00a016.92\u00a0nmol\/mL and 45.82\u00a0\u00b1\u00a04.02\u00a0U\/mL), and I\/R\u00a0+\u00a0lycopene group (176.02\u00a0\u00b1\u00a024.27\u00a0nmol\/mL and 35.20\u00a0\u00b1\u00a04.85\u00a0U\/mL). The histopathological analyses of I\/R\u00a0+\u00a0lycopene group indicated less significant changes than the control group. Tissue damage in the I\/R\u00a0+\u00a0lycopene group was less prominent than the I\/R group. These findings suggest oral lycopene supplementation as a promising prevention against skeletal muscle I\/R caused lung injury. <\/jats:p>","DOI":"10.1024\/0300-9831\/a000678","type":"journal-article","created":{"date-parts":[[2020,8,28]],"date-time":"2020-08-28T09:51:22Z","timestamp":1598608282000},"page":"240-247","source":"Crossref","is-referenced-by-count":2,"title":["Lycopene hampers lung injury due to skeletal muscle ischemia-reperfusion in rat model"],"prefix":"10.31083","volume":"92","author":[{"given":"Mehmet","family":"Kirisci","sequence":"first","affiliation":[{"name":"Kahramanmaras Sutcu Imam University, Faculty of Medicine, Department of Cardiovascular Surgery, Kahramanmaras, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1302-7531","authenticated-orcid":true,"given":"Bulent","family":"Guneri","sequence":"additional","affiliation":[{"name":"Kahramanmaras Sutcu Imam University, Faculty of Medicine, Department of 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