{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T16:41:21Z","timestamp":1789663281202,"version":"4.0.1"},"reference-count":39,"publisher":"IMR Press","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal for Vitamin and Nutrition Research"],"abstract":"<jats:p>Abstract. Caffeine has documented hypoalgesic effects during exercise. However, there is a lack of research focusing on caffeine\u2019s potential analgesic effects to ameliorate delayed onset muscle soreness. A placebo controlled randomized cross-over trial was carried out to determine if 5\u00a0mg\/kg of body weight (mg\/kgBW) of caffeine attenuates muscle pain and improves 5\u00a0k running performance following delayed onset muscle soreness. Prior to participating, eleven runners (9 male; 2 female; age, 24.5\u00a0\u00b1\u00a06.3\u00a0years; height, 173.6\u00a0\u00b1\u00a07.8\u00a0cm; body mass, 66.3\u00a0\u00b1\u00a07.5\u00a0kg; BMI, 23.18\u00a0kg\/m<jats:sup>2<\/jats:sup>\u00a0\u00b1\u00a01.6; VO<jats:sub>2max<\/jats:sub>61.0\u00a0\u00b1\u00a06.1\u00a0ml\/kg\/min<jats:sup>\u22121<\/jats:sup>), were asked to discontinue supplement use for 72 hours and abstain from caffeine consumption for 48 hours. Participants performed a 30-minute downhill run on a treadmill set at \u221210% grade at 70% VO<jats:sub>2max<\/jats:sub>to induce delayed onset of muscle soreness. Participants then returned 48 hours after to complete a 5\u00a0k time trial run where they consumed either 5\u00a0mg\/kgBW of caffeine or a placebo. Rate of perceived exertion and heart rate were taken every two minutes during the trial. There was no detectable statistical difference between 5\u00a0k performance between caffeine (1074.9\u00a0\u00b1\u00a0119.7 sec) or placebo (1053.8\u00a0\u00b1\u00a086.8 sec) ( p\u00a0=\u00a0.41). Algometer readings were similar between both treatments for muscle soreness in the rectus femoris ( p\u00a0=\u00a0.791) and the vastus medialis oblique ( p\u00a0=\u00a0.371). Muscle soreness ratings were found to be greater in the caffeine condition compared to the placebo condition ( p\u00a0=\u00a0.030). There was no effect of treatment on rating of perceived exertion between conditions ( p\u00a0=\u00a0.574). The present study suggests that caffeine is not effective at reducing muscle soreness, rating of perceived exertion, or improving running performance in a time trial in the presence of muscle soreness.<\/jats:p>","DOI":"10.1024\/0300-9831\/a000683","type":"journal-article","created":{"date-parts":[[2020,11,4]],"date-time":"2020-11-04T08:45:21Z","timestamp":1604479521000},"page":"1-9","source":"Crossref","is-referenced-by-count":2,"title":["No significant effect of caffeine on five kilometer running performance after muscle damage"],"prefix":"10.31083","author":[{"given":"Ali M.","family":"Al-Nawaiseh","sequence":"first","affiliation":[{"name":"Department of Sport Rehabilitation, The Hashemite University, Az-Zarqa, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert C.","family":"Pritchett","sequence":"additional","affiliation":[{"name":"Central Washington University, Ellensburg, Washington, 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