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All of these are currently at different stages of clinical trials. People with weak immunity are more prone to a severe infection of SARS-CoV-2. Therefore, early and judicious nutritional supplementation along with pharmacological treatment and clinician collaborations are critical in restituting the current situation. Nutritional supplements help in acquiring strong immunity to prevent the progression of disease any further. Vitamin C, vitamin D, selenium, zinc and many other nutritional and dietary supplements inhibit the production of inflammatory cytokines during a viral infection and prevents several unwanted symptoms of infection. Many dietary components like citrus fruits, black elderberry, ginger, and probiotics have the ability to attack viral replication. These supplements can also tame the overriding immune system during coronavirus infection. Keeping in view these facts, nutritional and dietary supplements can be used along with other management modalities. These nutritional and dietary supplements are potential candidates to curb the convulsive unfolding of novel COVID-19, in combination with other standard treatment protocols. In this review, various search engines were used to exploit available literature in order to provide a comprehensive review on nutritional and dietary supplements with respect to the viral infections. It will also provide a brief overview on some of the clinical trials that are in progress to assess the role of nutritional supplements, either alone or in combination with other pharmacological drugs, in fight against COVID-19. <\/jats:p>","DOI":"10.1024\/0300-9831\/a000715","type":"journal-article","created":{"date-parts":[[2021,6,8]],"date-time":"2021-06-08T09:27:17Z","timestamp":1623144437000},"page":"35-48","source":"Crossref","is-referenced-by-count":9,"title":["Immunomodulatory role and potential utility of various nutrients and \t\t\t\t\tdietary components in SARS-CoV-2 infection"],"prefix":"10.31083","volume":"92","author":[{"given":"Muhammad Osama","family":"Yaseen","sequence":"first","affiliation":[{"name":"Institute of Pharmaceutical Sciences, University of Veterinary & Animal Sciences, Lahore, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Humzah","family":"Jamshaid","sequence":"additional","affiliation":[{"name":"Institute of Pharmaceutical Sciences, University of Veterinary & Animal Sciences, Lahore, Pakistan"},{"name":"Department of Pharmacy, Quaid-e-Azam University, \t\t\t\t\t\tIslamabad, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arifa","family":"Saif","sequence":"additional","affiliation":[{"name":"Institute of Pharmaceutical Sciences, University of Veterinary & Animal Sciences, Lahore, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3508-8666","authenticated-orcid":true,"given":"Talib","family":"Hussain","sequence":"additional","affiliation":[{"name":"Institute of Pharmaceutical Sciences, University of Veterinary & Animal Sciences, Lahore, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"16242","reference":[{"key":"c1","doi-asserted-by":"publisher","DOI":"10.3390\/v11010041"},{"key":"c2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro.2016.81"},{"key":"c3","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30566-3"},{"key":"c4","unstructured":"Organization WH. \t\t\t\t\t\tCoronavirus disease 2019 (COVID-19): situation report, 67. \t\t\t\t\t\t2020."},{"key":"c5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2001316"},{"key":"c6","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.25689"},{"key":"c7","volume":"102433","author":"Rothan HA","year":"2020","journal-title":"J Autoimmun"},{"key":"c8","volume":"117900","author":"Yazdanpanah F","year":"2020","journal-title":"Life Sci"},{"key":"c9","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2020.00364"},{"key":"c10","author":"Fung M","year":"2020","journal-title":"Clin Infect Dis"},{"key":"c11","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30183-5"},{"key":"c12","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(13)70204-4"},{"key":"c13","volume":"1","author":"Thevarajan I","year":"2020","journal-title":"Nat Med"},{"key":"c14","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2007764"},{"key":"c15","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens9110917"},{"key":"c16","author":"Jaworski JP","year":"2020","journal-title":"Biomed J"},{"key":"c17","volume":"173751","author":"Rawat K","year":"2020","journal-title":"Eur J Pharmacol"},{"key":"c18","author":"Fadel R","year":"2020","journal-title":"MedRxiv"},{"key":"c19","doi-asserted-by":"publisher","DOI":"10.1016\/j.jand.2013.05.015"},{"issue":"1","key":"c20","first-page":"91","volume":"3","author":"Pae M","year":"2012","journal-title":"Aging Dis"},{"key":"c21","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2020.110834"},{"key":"c22","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-2863(96)00132-5"},{"key":"c23","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2891-5-21"},{"key":"c24","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2016.28.6.677"},{"key":"c25","volume":"1","author":"Hemil\u00e4 H","year":"2013","journal-title":"Cochrane Db Syst Rev"},{"key":"c26","doi-asserted-by":"publisher","DOI":"10.3390\/nu9111211"},{"key":"c27","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.171318198"},{"key":"c28","doi-asserted-by":"publisher","DOI":"10.1016\/j.jons.2015.11.010"},{"key":"c29","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268807008308"},{"key":"c30","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-0385"},{"key":"c31","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-0176"},{"key":"c32","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.14679"},{"key":"c33","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2018.00550"},{"key":"c34","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v9.i6.333"},{"key":"c35","unstructured":"NIH. 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