{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T11:21:15Z","timestamp":1762341675793,"version":"3.40.5"},"reference-count":38,"publisher":"IMR Press","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal for Vitamin and Nutrition Research"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:p> Abstract: In this study, children with vitamin B<jats:sub>12<\/jats:sub> deficiency anemia (V-B<jats:sub>12<\/jats:sub>DA) and control subjects were evaluated for erythrocyte glutathione peroxidase, catalase and superoxide dismutase enzyme activities, glutathione, malondialdehyde, serum total sialic acid, total antioxidant status, cobalt, chromium, copper, selenium, vanadium, zinc, iron, lead, magnesium, calcium, sodium, potassium, chloride, phosphorus levels, and the associations of these variables were assessed. The study included 50 children with V-B<jats:sub>12<\/jats:sub>DA and 50 control subjects. It was found that the V-B<jats:sub>12<\/jats:sub>DA group was significantly lower than the control group, with regard to the mean\u00b1the standard error of the mean levels of cobalt (0.089\u00b10.009; 0.058\u00b10.0063 \u03bcmol\/L, p&lt;0.01), selenium (2.19\u00b10.087; 1.88\u00b10.057 \u03bcmol\/L, p&lt;0.01), vanadium (1.31\u00b10.053; 1.18\u00b10.035 \u03bcmol\/L, p&lt;0.05), magnesium (3.02\u00b10.15; 2.73\u00b10.068 \u03bcmol\/L, p&lt;0.05), zinc (50.76\u00b11.96; 42.23\u00b1 1.53 \u03bcmol\/L, p&lt;0.001), and vitamin B<jats:sub>12<\/jats:sub> (427.20\u00b121.45; 157.08\u00b13.96 pg\/mL, p&lt;0.001). Moreover, a significant elevation in total sialic acid (1.44\u00b10.050; 1.61\u00b10.043 mmol\/L, p&lt;0.01), and mean corpuscular volume (MCV) (75.37\u00b10.95; 79.91\u00b11.14 fL, p&lt;0.01). It was observed that in the V-B<jats:sub>12<\/jats:sub>DA, significantly linear correlations were observed between cobalt \u2013 vitamin B<jats:sub>12<\/jats:sub> (r=0.334; p=0.025), vanadium \u2013 MCV (r=0.315; p=0.017), vitamin B<jats:sub>12<\/jats:sub> \u2013 MCV (r=\u22120.297; p=0.026). The findings of the study indicated that the levels of cobalt, vanadium significantly associated with traditional vitamin B<jats:sub>12-<\/jats:sub>deficiency parameters. Vitamin B<jats:sub>12<\/jats:sub> and MCV should be measured together with cobalt, vanadium for monitoring the vitamin B<jats:sub>12<\/jats:sub> deficiency anemia. <\/jats:p>","DOI":"10.1024\/0300-9831\/a000716","type":"journal-article","created":{"date-parts":[[2021,6,8]],"date-time":"2021-06-08T09:44:47Z","timestamp":1623145487000},"page":"132-141","source":"Crossref","is-referenced-by-count":2,"title":["Low vitamin B<sub>12<\/sub> level in relation to trace element, total sialic acid and antioxidant enzymes in children with vitamin B<sub>12<\/sub> deficiency anemia"],"prefix":"10.31083","volume":"93","author":[{"given":"Isa","family":"Kiran","sequence":"first","affiliation":[{"name":"Division of Blood and Transfusion, University of Health Sciences, Van Training and Research Hospital, Van, 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