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For Vitamin K2 (VK2), there is currently no official reference daily intake (RDI). However, the effects of VK2 on the improvement of health in cardiovascular diseases, on bone metabolism, on chronic kidney diseases have been the subject of research in recent decades. The microbiota in the gastrointestinal tract plays an important role: Bacteroides are primarily capable of synthetizing very long chain forms of menaquinones and, in addition to the bacteria present in the intestinal flora, VK2 is also produced by bacteria used in food fermentation processes. This review provides an update on the current literature regarding the origin of VK2 and its implications in what is called the \u201ccalcium paradox\u201d, namely the lack of calcium in the bone and its storage in the wall of the vessel. <\/jats:p>","DOI":"10.1024\/0300-9831\/a000761","type":"journal-article","created":{"date-parts":[[2022,8,30]],"date-time":"2022-08-30T06:00:01Z","timestamp":1661839201000},"page":"143-152","source":"Crossref","is-referenced-by-count":13,"title":["Role of vitamin K2 in bone-vascular crosstalk"],"prefix":"10.31083","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4753-3528","authenticated-orcid":true,"given":"Giuseppe","family":"Merra","sequence":"first","affiliation":[{"name":"Section of Clinical Nutrition and Nutrigenomic, Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, 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