{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T21:00:28Z","timestamp":1760043628385},"reference-count":0,"publisher":"IMR Press","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal for Vitamin and Nutrition Research"],"published-print":{"date-parts":[[1999,7,1]]},"abstract":"<jats:p> Administration of streptozotocin is used to induce diabetes in experimental models, causing a selective destruction of pancreatic beta islet cells associated with generation of free radicals. Supplementation with antioxidant vitamins such as vitamin E is a protective factor against free radicals. The objective of this study was to determine the effect of administration of a diet supplemented with, or deficient in vitamin E to streptozotocin diabetic rats, controlled or not with insulin, on plasma glucose, hepatic vitamin E and hepatic thiobarbituric acid reactive substance (TBARS) levels before streptozotocin and 24 hours and one and two weeks after drug administration. Deficiency of vitamin E alone increased TBARS levels, and streptozotocin elevated TBARS two times in deficient groups, regardless of insulin control. In rats supplemented with vitamin E, a reduction of plasma glucose and liver vitamin E was observed two weeks after streptozotocin administration (p &lt; 0.05). In conclusion, vitamin E supplementation probably protected against lipoperoxidation and contributed to the absence of elevation of plasma glucose levels, and vitamin E deficiency produced an increase in hepatic TBARS levels in streptozotocin diabetic rats. <\/jats:p>","DOI":"10.1024\/0300-9831.69.4.250","type":"journal-article","created":{"date-parts":[[2006,1,31]],"date-time":"2006-01-31T12:27:31Z","timestamp":1138710451000},"page":"250-254","source":"Crossref","is-referenced-by-count":9,"title":["Effect of Different Vitamin E Levels on Lipid Peroxidation in Streptozotocin-Diabetic Rats"],"prefix":"10.31083","volume":"69","author":[{"family":"Vannucchi","sequence":"first","affiliation":[{"name":"Division of Clinical Nutrition, Department of Internal Medicine, Faculty of Medicine of Ribeir\u00e3o Preto, University of S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Araujo","sequence":"additional","affiliation":[{"name":"Division of Clinical Nutrition, Department of Internal Medicine, Faculty of Medicine of Ribeir\u00e3o Preto, University of S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Bernardes","sequence":"additional","affiliation":[{"name":"Division of Clinical Nutrition, Department of Internal Medicine, Faculty of Medicine of Ribeir\u00e3o Preto, University of S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Jord\u00e3o-Jr","sequence":"additional","affiliation":[{"name":"Division of Clinical Nutrition, Department of Internal Medicine, Faculty of Medicine of Ribeir\u00e3o Preto, University of S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"16242","container-title":["International Journal for Vitamin and Nutrition Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/econtent.hogrefe.com\/doi\/pdf\/10.1024\/0300-9831.69.4.250","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T02:14:52Z","timestamp":1723169692000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.imrpress.com\/journal\/IJVNR\/69\/4\/10.1024\/0300-9831.69.4.250"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,7,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1999,7,1]]}},"alternative-id":["10.1024\/0300-9831.69.4.250"],"URL":"https:\/\/doi.org\/10.1024\/0300-9831.69.4.250","relation":{},"ISSN":["0300-9831","1664-2821"],"issn-type":[{"type":"print","value":"0300-9831"},{"type":"electronic","value":"1664-2821"}],"subject":[],"published":{"date-parts":[[1999,7,1]]}}}