{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:18:23Z","timestamp":1760188703480},"reference-count":0,"publisher":"IMR Press","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal for Vitamin and Nutrition Research"],"published-print":{"date-parts":[[1999,7,1]]},"abstract":"<jats:p> The potential of the antioxidant vitamin E to modulate the progress of the SLE-like (systemic lupus erythematosus) autoimmune disease in MRL\/MP-lpr\/lpr (MRL\/lpr) mice is described. Mice were orally supplemented with 0.4 mg vitamin E per day 5 times per week from week 8 of age onwards and compared with mice on a commercial or a vitamin E-deficient diet. Supplementation with vitamin E extended the mean survival time from 157 to 196 days; the massive spleen and lymph node enlargements were reduced; mitogenic responses of B and T cells were normalized; the abnormal differentiation patterns of thymic and splenic cell subpopulations were changed; titers of anti-double stranded DNA antibodies, concentrations of serum amyloid P component (SAP, an acute phase protein), and proteinuria were reduced. The results indicate that vitamin E beneficially affects the development of the SLE-like disease in MRL\/lpr mice suggesting a possible measure to reduce human SLE and probably various other autoimmune diseases in humans as well. <\/jats:p>","DOI":"10.1024\/0300-9831.69.4.255","type":"journal-article","created":{"date-parts":[[2006,1,31]],"date-time":"2006-01-31T12:27:31Z","timestamp":1138710451000},"page":"255-261","source":"Crossref","is-referenced-by-count":17,"title":["Inhibition of Autoimmune Deterioration in MRL\/lpr Mice by Vitamin E"],"prefix":"10.31083","volume":"69","author":[{"family":"Weimann","sequence":"first","affiliation":[{"name":"F. Hoffmann-La Roche Ltd., Vitamins and Fine Chemicals Divisions, Research and Development, 4070 Basel, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Hermann","sequence":"additional","affiliation":[{"name":"F. Hoffmann-La Roche Ltd., Vitamins and Fine Chemicals Divisions, Research and Development, 4070 Basel, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"16242","container-title":["International Journal for Vitamin and Nutrition Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/econtent.hogrefe.com\/doi\/pdf\/10.1024\/0300-9831.69.4.255","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T02:14:53Z","timestamp":1723169693000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.imrpress.com\/journal\/IJVNR\/69\/4\/10.1024\/0300-9831.69.4.255"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,7,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1999,7,1]]}},"alternative-id":["10.1024\/0300-9831.69.4.255"],"URL":"https:\/\/doi.org\/10.1024\/0300-9831.69.4.255","relation":{},"ISSN":["0300-9831","1664-2821"],"issn-type":[{"type":"print","value":"0300-9831"},{"type":"electronic","value":"1664-2821"}],"subject":[],"published":{"date-parts":[[1999,7,1]]}}}