{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,10]],"date-time":"2024-08-10T00:02:28Z","timestamp":1723248148007},"reference-count":0,"publisher":"IMR Press","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal for Vitamin and Nutrition Research"],"published-print":{"date-parts":[[2002,10,1]]},"abstract":"<jats:p> Phosphatidylcholine hydroperoxide (PCOOH) levels are increased in the iron-deficient rat liver. We investigated the antioxidative effect of dietary beta-carotene and altered retinol metabolism in iron-deficient rats. Experiment 1: Male Wistar-strain rats were divided into six groups and fed a control diet, an iron-deficient diet, and iron-deficient diets with four different levels of dietary beta-carotene. The PCOOH concentration in the iron-deficient rat liver was decreased by supplementation with dietary beta-carotene. However, the beta-carotene dose response was not related to antioxidative potency. Hepatic and plasma beta-carotene concentrations were increased by iron deficiency. The hepatic retinol concentration was increased while the plasma retinol concentration was decreased in iron-deficient rats. Experiment 2: Male Wistar-strain rats were divided into two groups, with one group receiving a control diet with beta-carotene and the other an iron-deficient diet with beta-carotene. Intestinal iron was decreased and intestinal beta-carotene was unchanged in iron-deficient rats. The intestinal beta-carotene conversion ratio and beta-carotene cleavage enzyme activity were decreased in iron-deficient rats. Dietary beta-carotene played the role of an antioxidant in hepatic lipid peroxidation in the iron-deficient state, but there was no dose dependency. Moreover, intestinal beta-carotene cleavage and hepatic retinol release appear to be altered in iron-deficient rats. <\/jats:p>","DOI":"10.1024\/0300-9831.72.5.321","type":"journal-article","created":{"date-parts":[[2006,1,31]],"date-time":"2006-01-31T12:28:23Z","timestamp":1138710503000},"page":"321-328","source":"Crossref","is-referenced-by-count":5,"title":["Dose-Responsive Alteration in Hepatic Lipid Peroxidation and Retinol Metabolism with Increasing Dietary beta-Carotene in Iron Deficient Rats"],"prefix":"10.31083","volume":"72","author":[{"given":"Ryouko","family":"Ikeda","sequence":"first","affiliation":[{"name":"Department of Nutritional Science, Faculty of Applied Bio-Science, Tokyo University of Agriculture, Sakuragaoka 1-1-1, Setagaya-Ku, Tokyo 156-8502, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariko","family":"Uehara","sequence":"additional","affiliation":[{"name":"Department of Nutritional Science, Faculty of Applied Bio-Science, Tokyo University of Agriculture, Sakuragaoka 1-1-1, Setagaya-Ku, Tokyo 156-8502, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Misao","family":"Takasaki","sequence":"additional","affiliation":[{"name":"Department of Nutritional Science, Faculty of Applied Bio-Science, Tokyo University of Agriculture, Sakuragaoka 1-1-1, Setagaya-Ku, Tokyo 156-8502, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshige","family":"Chiba","sequence":"additional","affiliation":[{"name":"Department of Nutritional Science, Faculty of Applied Bio-Science, Tokyo University of Agriculture, Sakuragaoka 1-1-1, Setagaya-Ku, Tokyo 156-8502, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ritsuko","family":"Masuyama","sequence":"additional","affiliation":[{"name":"Department of Nutritional Science, Faculty of Applied Bio-Science, Tokyo University of Agriculture, Sakuragaoka 1-1-1, Setagaya-Ku, Tokyo 156-8502, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadasu","family":"Furusho","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Junior College of Tokyo University of Agriculture, Sakuragaoka 1-1-1, Setagaya-Ku, Tokyo 156-8502, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuharu","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Nutritional Science, Faculty of Applied Bio-Science, Tokyo University of Agriculture, Sakuragaoka 1-1-1, Setagaya-Ku, Tokyo 156-8502, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"16242","container-title":["International Journal for Vitamin and Nutrition Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/econtent.hogrefe.com\/doi\/pdf\/10.1024\/0300-9831.72.5.321","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T02:14:07Z","timestamp":1723169647000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.imrpress.com\/journal\/IJVNR\/72\/5\/10.1024\/0300-9831.72.5.321"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,10,1]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2002,10,1]]}},"alternative-id":["10.1024\/0300-9831.72.5.321"],"URL":"https:\/\/doi.org\/10.1024\/0300-9831.72.5.321","relation":{},"ISSN":["0300-9831","1664-2821"],"issn-type":[{"type":"print","value":"0300-9831"},{"type":"electronic","value":"1664-2821"}],"subject":[],"published":{"date-parts":[[2002,10,1]]}}}