{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T21:26:19Z","timestamp":1774128379550,"version":"3.50.1"},"reference-count":0,"publisher":"IMR Press","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal for Vitamin and Nutrition Research"],"published-print":{"date-parts":[[2003,12,1]]},"abstract":"<jats:p> The acute phase response is known to affect many biological parameters used to assess the iron and vitamin A status. Usually, C-reactive protein (CRP) values higher than 5 to 10 mg\/L are taken as indicative of this response. Here we report changes occurring at much lower CRP values. A range of parameters (clinical chemistry, retinol, vitamin E, carotenoids, thyroid status, blood count, immunology) were measured in 101 healthy one-year-old children with no or only minimal symptoms of airway infection and CRP values below 6 mg\/L on routine testing. Additionally, CRP values were measured by a high-sensitivity assay (detection limit 0.2 mg\/L). When determined by a more sensitive assay, CRP values (median, 0.26 mg\/L) revealed highly significant associations with parameters known to be influenced by the acute phase response. Using a limit of 0.6 mg\/L (75th percentile), significantly lower levels were observed for transthyretin, iron, retinol, and beta-carotene in the group with the higher CRP levels. This relationship was confirmed intra-individually in a subgroup of 21 children who underwent a second blood draw about four weeks after the first one. The acute phase response is triggered at very low inflammatory levels with CRP values considerably lower than 5 to 10 mg\/L, and can occur in apparently healthy children. A high-sensitivity CRP assay is necessary to detect this low level, and in the case of iron or vitamin A, it can help to avoid misclassification of the nutritional status. <\/jats:p>","DOI":"10.1024\/0300-9831.73.6.423","type":"journal-article","created":{"date-parts":[[2006,1,31]],"date-time":"2006-01-31T12:28:49Z","timestamp":1138710529000},"page":"423-430","source":"Crossref","is-referenced-by-count":43,"title":["Minimal Inflammation, Acute Phase Response and Avoidance of Misclassification of Vitamin A and Iron Status in Infants \u2013 Importance of a High-Sensitivity C-Reactive Protein (CRP) Assay"],"prefix":"10.31083","volume":"73","author":[{"family":"Abraham","sequence":"first","affiliation":[{"name":"Department of Pediatric Pneumology and Immunology, University Clinic Charit\u00e9, Humboldt University Berlin, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathobiochemistry, University Clinic Charit\u00e9, Humboldt University Berlin, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Gr\u00fcters","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology, University Clinic Charit\u00e9, Humboldt University Berlin, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Wahn","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pneumology and Immunology, University Clinic Charit\u00e9, Humboldt University Berlin, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Schweigert","sequence":"additional","affiliation":[{"name":"Institute of Nutritional Science, University of Potsdam, Potsdam-Rehbr\u00fccke, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"16242","container-title":["International Journal for Vitamin and Nutrition Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/econtent.hogrefe.com\/doi\/pdf\/10.1024\/0300-9831.73.6.423","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T02:13:10Z","timestamp":1723169590000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.imrpress.com\/journal\/IJVNR\/73\/6\/10.1024\/0300-9831.73.6.423"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,12,1]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2003,12,1]]}},"alternative-id":["10.1024\/0300-9831.73.6.423"],"URL":"https:\/\/doi.org\/10.1024\/0300-9831.73.6.423","relation":{},"ISSN":["0300-9831","1664-2821"],"issn-type":[{"value":"0300-9831","type":"print"},{"value":"1664-2821","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,12,1]]}}}