{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T15:20:11Z","timestamp":1783783211060,"version":"3.55.0"},"reference-count":0,"publisher":"IMR Press","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal for Vitamin and Nutrition Research"],"published-print":{"date-parts":[[2007,1,1]]},"abstract":"<jats:p> Background: Hyperhomocysteinemia is an accepted risk factor for cardiovascular disease, and possibly also for cognitive impairment and dementia. It has also been proposed as a marker for the status of the B vitamins, which participate in the metabolism of homocysteine. Therefore, especially in the elderly, it is important to know the prevalence of high homocysteine (tHcy) levels and the influence that B vitamins have on them. Material and Methods: 218 elderly of both sexes, aged 60\u2013105, living in an elderly home in Granada (Spain), were screened for serum folate, red blood cell (RBC) folate, serum cobalamin (B<jats:sub>12<\/jats:sub>) (Abbott, IMx), holotranscobalamin II (Holo-TC II) (HoloTC RIA, Axis-Shield), methylmalonic acid (MMA) (MS-GC), total pyridoxine (B<jats:sub>6<\/jats:sub>) (HPLC), and total homocysteine (tHcy) (Abbott, IMx). Results: Hyperhomocysteinemia (tHcy &gt; 12 \u03bcmol\/L) was detected in 80.7%. Serum folate deficiency was severe (\u2264 4 ng\/mL) in 19.3% and moderate (4\u20137 ng\/mL) in 43.1%. In 14.2% of the elderly RBC folate was \u2264 175 ng\/mL, and in 61.0% it was between 175\u2013400 ng\/mL. Vitamin B<jats:sub>12<\/jats:sub>, measured in serum (\u2264 200 pg\/mL), was deficient in 15.8%, but if measured as Holo-TC II (\u2264 45 pmol\/L), deficiency ranged up to 39.1%. MMA was high (\u2265 300 nmol\/L) in 45.6%. Vitamin B<jats:sub>6<\/jats:sub> (&lt; 20 nmol\/L) was low only in one person. In order to identify the factors that could predict tHcy levels, a multiple regression analysis was performed. Best results corresponded to the combination of log serum folate and log Holo-TC II, which gave values of R &gt; 0.5. If analyzed independently, the highest correlation was with log serum folate (r = \u20130.290), followed by RBC folate (r = \u20130.263), Holo-TC II (r = \u20130.228), log B<jats:sub>12<\/jats:sub> (r = \u20130.175), and log B<jats:sub>6<\/jats:sub> (r = \u20130.078). Conclusion: There is a high prevalence of vitamin B deficiency and hyperhomocysteinemia in the studied population. Our data confirm the influence of these vitamins, especially folate, on tHcy levels, but hyperhomocysteinemia cannot be used as the only diagnostic criterion to detect subclinical vitamin deficiency in elderly people, especially to detect vitamin B<jats:sub>12<\/jats:sub> deficiency. <\/jats:p>","DOI":"10.1024\/0300-9831.77.1.22","type":"journal-article","created":{"date-parts":[[2007,4,13]],"date-time":"2007-04-13T02:30:06Z","timestamp":1176431406000},"page":"22-33","source":"Crossref","is-referenced-by-count":28,"title":["B-Vitamins and Homocysteine in Spanish Institutionalized Elderly"],"prefix":"10.31083","volume":"77","author":[{"family":"Gonzalez-Gross","sequence":"first","affiliation":[{"name":"Grupo Effects 262, Facultad de Medicina, Universidad de Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Sola","sequence":"additional","affiliation":[{"name":"Grupo Effects 262, Facultad de Medicina, Universidad de Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Albers","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias de la Actividad F\u00edsica y del Deporte. Universidad Polit\u00e9cnica de Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Barrios","sequence":"additional","affiliation":[{"name":"Centro T\u00e9cnico de Inform\u00e1tica, Consejo Superior de Investigaciones Cient\u00edficas, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Alder","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias de la Actividad F\u00edsica y del Deporte. Universidad Polit\u00e9cnica de Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Castillo","sequence":"additional","affiliation":[{"name":"Grupo Effects 262, Facultad de Medicina, Universidad de Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Pietrzik","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Ern\u00e4hrungs-und Lebensmittelwissenschaften, Pathophysiologie der Ern\u00e4hrung, Rheinische Friedrichs-Wilhelms Universit\u00e4t Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"16242","container-title":["International Journal for Vitamin and Nutrition Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/econtent.hogrefe.com\/doi\/pdf\/10.1024\/0300-9831.77.1.22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T02:11:45Z","timestamp":1723169505000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.imrpress.com\/journal\/IJVNR\/77\/1\/10.1024\/0300-9831.77.1.22"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,1,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,1,1]]}},"alternative-id":["10.1024\/0300-9831.77.1.22"],"URL":"https:\/\/doi.org\/10.1024\/0300-9831.77.1.22","relation":{},"ISSN":["0300-9831","1664-2821"],"issn-type":[{"value":"0300-9831","type":"print"},{"value":"1664-2821","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,1,1]]}}}