{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T01:27:23Z","timestamp":1775179643669,"version":"3.50.1"},"reference-count":0,"publisher":"IMR Press","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal for Vitamin and Nutrition Research"],"published-print":{"date-parts":[[2008,5,1]]},"abstract":"<jats:p> Background: Although a number of reports regarding the role of reactive oxygen species (ROS) as the first step in cancer induction exist, few studies have investigated how vitamin C influences ROS in human plasma. Aim of the study: Using the ROS assay system, a method recently established by one of the authors, we aimed to evaluate the effect of vitamin C supplementation on serum ROS among subjects diagnosed with chronic gastritis. Methods: A total of 244 Japanese subjects with atrophic gastritis were randomized to take 5-year supplementation of either 50 mg or 500 mg of vitamin C. Results: The adjusted difference in the changes of total ROS between baseline and after 5-year supplementation was statistically significant between the intervention groups: 2.70 decrease (corresponds to 1.26% decrease) in the high-dose group and 4.16 increase (corresponds to 3.79% increase) in the low-dose group, p for difference = 0.01. Conclusion: Vitamin C was suggested to reduce oxidative stress among subjects with atrophic gastritis. <\/jats:p>","DOI":"10.1024\/0300-9831.78.3.121","type":"journal-article","created":{"date-parts":[[2008,11,11]],"date-time":"2008-11-11T03:30:37Z","timestamp":1226374237000},"page":"121-128","source":"Crossref","is-referenced-by-count":32,"title":["Protective Effect of Vitamin C on Oxidative Stress: a Randomized Controlled Trial"],"prefix":"10.31083","volume":"78","author":[{"family":"Sasazuki","sequence":"first","affiliation":[{"name":"Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening National Cancer Center, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan, ssasazuk@gan2.res.ncc.go.jp"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Hayashi","sequence":"additional","affiliation":[{"name":"Department of Radiobiology\/Molecular Epidemiology, Radiation Effects Research Foundation, 5-2 Hijiyama Park, Minami Ward, Hiroshima 732-0815"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Nakachi","sequence":"additional","affiliation":[{"name":"Department of Radiobiology\/Molecular Epidemiology, Radiation Effects Research Foundation, 5-2 Hijiyama Park, Minami Ward, Hiroshima 732-0815"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Sasaki","sequence":"additional","affiliation":[{"name":"Division of Dietary Reference Intakes, National Institute of Health and Nutrition, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8636"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Tsubono","sequence":"additional","affiliation":[{"name":"Division of Epidemiology, Department of Public Health and Forensic Medicine, Tohoku University Graduate School of Medicine, Sendai 980-8575"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Okubo","sequence":"additional","affiliation":[{"name":"Hiraka General Hospital, 1-30 Ekimae-cho, Yokote 013-8610"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Hayashi","sequence":"additional","affiliation":[{"name":"Hiraka General Hospital, 1-30 Ekimae-cho, Yokote 013-8610"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Tsugane","sequence":"additional","affiliation":[{"name":"Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening National Cancer Center, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"16242","container-title":["International Journal for Vitamin and Nutrition Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/econtent.hogrefe.com\/doi\/pdf\/10.1024\/0300-9831.78.3.121","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T02:11:11Z","timestamp":1723169471000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.imrpress.com\/journal\/IJVNR\/78\/3\/10.1024\/0300-9831.78.3.121"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,5,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008,5,1]]}},"alternative-id":["10.1024\/0300-9831.78.3.121"],"URL":"https:\/\/doi.org\/10.1024\/0300-9831.78.3.121","relation":{},"ISSN":["0300-9831","1664-2821"],"issn-type":[{"value":"0300-9831","type":"print"},{"value":"1664-2821","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,5,1]]}}}