{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T12:04:39Z","timestamp":1761393879459},"reference-count":0,"publisher":"IMR Press","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal for Vitamin and Nutrition Research"],"published-print":{"date-parts":[[2009,3,1]]},"abstract":"<jats:p> Carotenoids are colored molecules that are widespread in the plant kingdom, but animals cannot synthesize them. Carotenes are long, apolar molecules which require fully functioning digestive processes to be absorbed properly. Hence they could be interesting markers of intestinal absorption and digestion. Indeed, only few tests are available to assess these processes and only the D-xylose tolerance test is routinely used. However D-xylose is a sugar that tests only the absorption of water-soluble compounds and it only tests duodenal absorption. In this study, we have evaluated carotenoids as markers of digestion and absorption. We compared fasting plasma carotenoids concentrations in 21 control subjects, 20 patients with Crohn\u2019s disease, and 18 patients with pancreatic cancer. Crohn\u2019s disease alters intestinal absorption while pancreatic cancer decreases pancreatic enzyme secretion thus impairing digestion. Results show that all carotenoids are significantly lower in Crohn\u2019s and cancer patients as compared to control subjects and the multifactorial analysis shows that this decrease is mostly independent of dietary intake. Interestingly, maldigestion as seen in pancreatic cancer more strongly influences plasma lutein and lycopene concentrations while malabsorption in Crohn\u2019s disease acts on other carotenoids. Thus carotenoids could be interesting alternatives for testing and following patients that are suspected of having malabsorption or maldigestion syndromes. <\/jats:p>","DOI":"10.1024\/0300-9831.79.2.87","type":"journal-article","created":{"date-parts":[[2010,1,28]],"date-time":"2010-01-28T03:31:33Z","timestamp":1264649493000},"page":"87-94","source":"Crossref","is-referenced-by-count":10,"title":["Fasting plasma carotenoids concentrations in Crohn\u2019s and pancreatic cancer patients compared to control subjects"],"prefix":"10.31083","volume":"79","author":[{"family":"Drai","sequence":"first","affiliation":[{"name":"Biochimie m\u00e9tabolique et mol\u00e9culaire\u2013Centre hospitalier sud, 165 chemin du grand Revoyet\u201369495 Pierre B\u00e9nite\u2013France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Borel","sequence":"additional","affiliation":[{"name":"INRA UMR1260 \u00abNutriments Lipidiques et Pr\u00e9vention des Maladies M\u00e9taboliques\u00bb, Marseille, F-13385 France\u2013INSERM, U476, Marseille, F-13385 France\u2013Universit\u00e9 Aix-Marseille 1, Universit\u00e9 Aix-Marseille 2, Facult\u00e9 de M\u00e9decine IPHM-IFR 125, Marseille, F-13385 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Faure","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Biologie Int\u00e9gr\u00e9e\u2013CHU La Tronche\u2013B\u00e2timent B BP 217, 38043 Grenoble Cedex France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Galabert","sequence":"additional","affiliation":[{"name":"Laboratoire de biologie\u2013H\u00f4pital Ren\u00e9e Sabran\u2013Boulevard Edouard Herriot, 83406 Hy\u00e8res\u2013France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Le Mo\u00ebl","sequence":"additional","affiliation":[{"name":"French Society for Vitamins and Biofactors, 17 rue Maurice Lachatre\u201393120 La Courneuve\u2013France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Laromigui\u00e8re","sequence":"additional","affiliation":[{"name":"Laboratoire de biochimie A\u2013H\u00f4tel Dieu\u2013Place du parvis Notre Dame, 75007 Paris\u2013France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Fayol","sequence":"additional","affiliation":[{"name":"Laboratoire Analyses M\u00e9dicale -54 avenue Paul Doumer, 69630 Chaponost\u2013France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"16242","container-title":["International Journal for Vitamin and Nutrition Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/econtent.hogrefe.com\/doi\/pdf\/10.1024\/0300-9831.79.2.87","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T02:11:01Z","timestamp":1723169461000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.imrpress.com\/journal\/IJVNR\/79\/2\/10.1024\/0300-9831.79.2.87"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,3,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009,3,1]]}},"alternative-id":["10.1024\/0300-9831.79.2.87"],"URL":"https:\/\/doi.org\/10.1024\/0300-9831.79.2.87","relation":{},"ISSN":["0300-9831","1664-2821"],"issn-type":[{"type":"print","value":"0300-9831"},{"type":"electronic","value":"1664-2821"}],"subject":[],"published":{"date-parts":[[2009,3,1]]}}}