{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,5,8]],"date-time":"2022-05-08T12:10:57Z","timestamp":1652011857029},"reference-count":0,"publisher":"Hogrefe Publishing Group","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vasa"],"published-print":{"date-parts":[[2011,11,1]]},"abstract":"<jats:p> Background: Several studies have demonstrated that the proteasome inhibitors prevent restenosis following arterial injury. The proteasome inhibitor bortezomib shows anti-inflammatory and antiproliferative effects. Here, we evaluate the efficacy of bortezomib in inhibiting the restenosis following arterial injury and the effect on nuclear factor kappa B (NF-kappaB) and p27. Methods: An injured iliac artery rabbit model was established by balloon over-stretching. Rabbits were intramurally infused with bortezomib or normal saline by a transport coronary dilatation catheter in the bortezomib (n = 20) or control (n = 20) groups, respectively, and they were sacrificed on the 7th or 21th day following the arterial injury. Neointimal area was measured by computer analysis of photomicrographs, while expression of NF-kappaB and of p27 on day 7 were evaluated by Western blotting and immunohistochemistry, respectively. Results: Expression of p27 (56.10 \u00b1 3.03% vs. 10.24 \u00b1 0.60%, p &lt; 0.05) was significantly higher while that of NF-kappaB (0.44 \u00b1 0.02 vs. 0.70 \u00b1 0.03, p &lt; 0.05) was significantly lower in the bortezomib group than in control group on day 7 after arterial injury. Neointimal formation was significantly lower in the bortezomib group on day 21 after arterial injury (0.67 \u00b1 0.03 vs. 1.30 \u00b1 0.05 intima\/media ratio, p &lt; 0.05). Conclusions: Intramural delivery of bortezomib reduces neointimal formation, possibly via a mechanism involving upregulation of the p27 and downregulation of the NF-kappaB. Bortezomib therefore may be an alternative therapeutic approach for preventing restenosis. <\/jats:p>","DOI":"10.1024\/0301-1526\/a000147","type":"journal-article","created":{"date-parts":[[2013,2,2]],"date-time":"2013-02-02T02:21:08Z","timestamp":1359771668000},"page":"449-452","source":"Crossref","is-referenced-by-count":0,"title":["Intramural delivery of bortezomib inhibits restenosis following arterial injury"],"prefix":"10.1024","volume":"40","author":[{"family":"Gong","sequence":"first","affiliation":[{"name":"Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing , China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"101","container-title":["Vasa"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/econtent.hogrefe.com\/doi\/pdf\/10.1024\/0301-1526\/a000147","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,8]],"date-time":"2022-05-08T11:52:13Z","timestamp":1652010733000},"score":1,"resource":{"primary":{"URL":"https:\/\/econtent.hogrefe.com\/doi\/10.1024\/0301-1526\/a000147"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,11,1]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2011,11,1]]}},"alternative-id":["10.1024\/0301-1526\/a000147"],"URL":"https:\/\/doi.org\/10.1024\/0301-1526\/a000147","relation":{},"ISSN":["0301-1526","1664-2872"],"issn-type":[{"value":"0301-1526","type":"print"},{"value":"1664-2872","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,11,1]]}}}