{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T17:26:13Z","timestamp":1787678773669,"version":"build-2784847793"},"reference-count":0,"publisher":"Hogrefe Publishing Group","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vasa"],"published-print":{"date-parts":[[2014,11,1]]},"abstract":"<jats:p> The Renin-Angiotensin system plays an important role in the regulation of systemic blood pressure as well as in fluid and electrolyte balance. It is divided into two described axes, the ACE \u2013 Ang II \u2013 AT1 receptor, with Ang II as the main mediator, and the ACE2 \u2013 Ang-(1\u20137) \u2013 Mas receptor, with Ang-(1\u20137) responsible for the main effects. The main vascular effect induced by Ang II is contraction, while Ang-(1\u20137) includes relaxation in several vascular beds. Ang II also activates several cytokines that are important in the genesis of vascular inflammation and hypertrophy. In this context, Ang-(1\u20137) seems to have a protective role. Both AT1 and Mas receptors modulate, in different ways, the generation of, which are involved in the control of vascular tone and the genesis of vascular dysfunction triggered by several diseases, including diabetes mellitus, arterial hypertension and atherosclerosis. Thereby, this review presents an overview of the modulation played by the whole Renin-Angiotensin system on the reactive oxygen species-mediated control of vascular tone and the oxidative stress-elicited vascular dysfunction. <\/jats:p>","DOI":"10.1024\/0301-1526\/a000387","type":"journal-article","created":{"date-parts":[[2014,10,23]],"date-time":"2014-10-23T01:53:48Z","timestamp":1414029228000},"page":"404-414","source":"Crossref","is-referenced-by-count":23,"title":["Counter-regulatory effects played by the ACE \u2013 Ang II \u2013 AT1 and ACE2 \u2013 Ang-(1\u20137) \u2013 Mas axes on the reactive oxygen species-mediated control of vascular function: perspectives to pharmacological approaches in controlling vascular complications"],"prefix":"10.1024","volume":"43","author":[{"given":"Laena","family":"Pernomian","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Faculty of Medicine of Ribeir\u00e3o Preto, University of S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larissa","family":"Pernomian","sequence":"additional","affiliation":[{"name":"Department of Physics and Chemistry, Faculty of Pharmaceutical Sciences of Ribeir\u00e3o Preto, University of S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Baraldi Ara\u00fajo Restini","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Ribeir\u00e3o Preto, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"101","container-title":["Vasa"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/econtent.hogrefe.com\/doi\/pdf\/10.1024\/0301-1526\/a000387","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,17]],"date-time":"2021-03-17T08:09:59Z","timestamp":1615968599000},"score":1,"resource":{"primary":{"URL":"https:\/\/econtent.hogrefe.com\/doi\/10.1024\/0301-1526\/a000387"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11,1]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,11,1]]}},"alternative-id":["10.1024\/0301-1526\/a000387"],"URL":"https:\/\/doi.org\/10.1024\/0301-1526\/a000387","relation":{},"ISSN":["0301-1526","1664-2872"],"issn-type":[{"value":"0301-1526","type":"print"},{"value":"1664-2872","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,11,1]]}}}