{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T22:12:43Z","timestamp":1780438363394,"version":"3.54.1"},"reference-count":0,"publisher":"Hogrefe Publishing Group","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vasa"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:p> Abstract. Summary: The term \u201cLDL hypothesis\u201d is frequently used to describe the association of low-density lipoprotein cholesterol (LDL-cholesterol, LDL-C) and cardiovascular (CV) events. Recent data from genetic studies prove a causal relation between serum LDL-C and CV events. These data are in agreement with mechanistic molecular studies and epidemiology. New randomised clinical trial data show that LDL-C lowering with statins and a non-statin drug, ezetimibe, reduces CV events. We therefore believe that the \u201cLDL-hypothesis\u201d has been proven; the term appears to be outdated and should be replaced by \u201cLDL causality\u201d. <\/jats:p>","DOI":"10.1024\/0301-1526\/a000451","type":"journal-article","created":{"date-parts":[[2015,8,28]],"date-time":"2015-08-28T16:38:51Z","timestamp":1440779931000},"page":"333-340","source":"Crossref","is-referenced-by-count":11,"title":["Moving beyond the \u201cLDL hypothesis\u201d"],"prefix":"10.1024","volume":"44","author":[{"given":"Christian","family":"Werner","sequence":"first","affiliation":[{"name":"Clinic for Internal Medicine III - Cardiology, Angiology and Internal Intensive Medicine, Saarland University Hospital, Homburg\/Saar, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Laufs","sequence":"additional","affiliation":[{"name":"Clinic for Internal Medicine III - Cardiology, Angiology and Internal Intensive Medicine, Saarland University Hospital, Homburg\/Saar, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"101","container-title":["Vasa"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/econtent.hogrefe.com\/doi\/pdf\/10.1024\/0301-1526\/a000451","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,17]],"date-time":"2021-03-17T04:40:31Z","timestamp":1615956031000},"score":1,"resource":{"primary":{"URL":"https:\/\/econtent.hogrefe.com\/doi\/10.1024\/0301-1526\/a000451"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["10.1024\/0301-1526\/a000451"],"URL":"https:\/\/doi.org\/10.1024\/0301-1526\/a000451","relation":{},"ISSN":["0301-1526","1664-2872"],"issn-type":[{"value":"0301-1526","type":"print"},{"value":"1664-2872","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9]]}}}