{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T23:48:25Z","timestamp":1784072905545,"version":"3.55.0"},"reference-count":0,"publisher":"Hogrefe Publishing Group","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vasa"],"published-print":{"date-parts":[[2017,5,1]]},"abstract":"<jats:p> Abstract. Background: Aortic dilatation in Marfan syndrome (MFS) is progressive. It is associated with oxidative stress and endothelial dysfunction that contribute to the early acute dissection of the vessel and can result in rupture of the aorta and sudden death. We evaluated the participation of the glutathione (GSH) system, which could be involved in the mechanisms that promote the formation and progression of the aortic aneurysms in MFS patients. Patients and methods: Aortic aneurysm tissue was obtained during chest surgery from eight control subjects and 14 MFS patients. Spectrophotometrical determination of activity of glutathione peroxidase (GPx), glutathione-S-transferase (GST), glutathione reductase (GR), lipid peroxidation (LPO) index, carbonylation, total antioxidant capacity (TAC), and concentration of reduced and oxidized glutathione (GSH and GSSG respectively), was performed in the homogenate from aortic aneurysm tissue. Results: LPO index, carbonylation, TGF-\u03b21, and GR activity were increased in MFS patients (p &lt; 0.04), while TAC, GSH\/GSSG ratio, GPx, and GST activity were significantly decreased (p &lt; 0.04). Conclusions: The depletion of GSH, in spite of the elevated activity of GR, not only diminished the activity of GSH-depend GST and GPx, but increased LPO, carbonylation and decreased TAC. These changes could promote the structural and functional alterations in the thoracic aorta of MFS patients. <\/jats:p>","DOI":"10.1024\/0301-1526\/a000609","type":"journal-article","created":{"date-parts":[[2017,2,8]],"date-time":"2017-02-08T09:37:07Z","timestamp":1486546627000},"page":"177-186","source":"Crossref","is-referenced-by-count":28,"title":["Glutathione system participation in thoracic aneurysms from patients                     with Marfan syndrome"],"prefix":"10.1024","volume":"46","author":[{"given":"Alejandra Mar\u00eda","family":"Z\u00fa\u00f1iga-Mu\u00f1oz","sequence":"first","affiliation":[{"name":"Pathology, Instituto Nacional de                     Cardiolog\u00eda Ignacio Ch\u00e1vez, M\u00e9xico City, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Israel","family":"P\u00e9rez-Torres","sequence":"additional","affiliation":[{"name":"Pathology, Instituto Nacional de                     Cardiolog\u00eda Ignacio Ch\u00e1vez, M\u00e9xico City, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ver\u00f3nica","family":"Guarner-Lans","sequence":"additional","affiliation":[{"name":"Physiology, Instituto Nacional de                     Cardiolog\u00eda Ignacio Ch\u00e1vez, M\u00e9xico City, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"El\u00edas","family":"N\u00fa\u00f1ez-Garrido","sequence":"additional","affiliation":[{"name":"Cardiothoracic Surgery, Instituto Nacional                     de Cardiolog\u00eda Ignacio Ch\u00e1vez, M\u00e9xico City, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo","family":"Vel\u00e1zquez Espejel","sequence":"additional","affiliation":[{"name":"Pathology, Instituto Nacional de                     Cardiolog\u00eda Ignacio Ch\u00e1vez, M\u00e9xico City, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Huesca-G\u00f3mez","sequence":"additional","affiliation":[{"name":"Physiology, Instituto Nacional de                     Cardiolog\u00eda Ignacio Ch\u00e1vez, M\u00e9xico City, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Gamboa-\u00c1vila","sequence":"additional","affiliation":[{"name":"Physiology, Instituto Nacional de                     Cardiolog\u00eda Ignacio Ch\u00e1vez, M\u00e9xico City, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Elena","family":"Soto","sequence":"additional","affiliation":[{"name":"Departaments of Immunology, Instituto                     Nacional de Cardiolog\u00eda Ignacio Ch\u00e1vez, M\u00e9xico City,                     M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"101","container-title":["Vasa"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/econtent.hogrefe.com\/doi\/pdf\/10.1024\/0301-1526\/a000609","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,17]],"date-time":"2021-03-17T07:35:18Z","timestamp":1615966518000},"score":1,"resource":{"primary":{"URL":"https:\/\/econtent.hogrefe.com\/doi\/10.1024\/0301-1526\/a000609"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,5,1]]}},"alternative-id":["10.1024\/0301-1526\/a000609"],"URL":"https:\/\/doi.org\/10.1024\/0301-1526\/a000609","relation":{},"ISSN":["0301-1526","1664-2872"],"issn-type":[{"value":"0301-1526","type":"print"},{"value":"1664-2872","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5,1]]}}}