{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T13:05:09Z","timestamp":1777899909133,"version":"3.51.4"},"reference-count":22,"publisher":"Hogrefe Publishing Group","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vasa"],"published-print":{"date-parts":[[2018,8,1]]},"abstract":"<jats:p> Abstract. Background: Treating great and small saphenous vein trunk insufficiency with cyanoacrylate glue is the least taxing treatment method of all available techniques. Due to long-term unavailability of commercial kits with n-butyl-2-cyanoacrylate (histoacryl) in the Czech Republic, we used a modified technique. Patients and methods: Fifty-six limbs in 49 patients suffering from great saphenous vein or small saphenous vein insufficiency in combination with symptomatic chronic venous insufficiency and complicating comorbidities were treated with a modified endovascular cyanoacrylate glue application technique. Results: The immediate success rate of the treatment was 98 %. In follow-up intervals of six weeks, six months, one year, and two years, the anatomical success rates of embolization (recanalization of no more than 5 cm of the junction) were 98, 96, 94, and 94 %, respectively. At identical intervals the venous insufficiency was scored according to the Aberdeen Varicose Vein Questionnaire and the American Venous Clinical Severity Score. In both cases, improvement was demonstrated over the two-year follow-up, with a 0.5 % significance level. Specific clinical signs of venous insufficiency were also evaluated, such as pain, oedema, clearance of varicose veins, and healing of venous ulceration. One severe complication \u2013 a pulmonary embolism \u2013 was reported, without consequences. Conclusions: We demonstrated that treating insufficient saphenous veins with modified histoacryl application brought a relief from symptoms of venous insufficiency and that the efficiency of this technique is comparable to commonly used methods. <\/jats:p>","DOI":"10.1024\/0301-1526\/a000716","type":"journal-article","created":{"date-parts":[[2018,6,12]],"date-time":"2018-06-12T07:35:12Z","timestamp":1528788912000},"page":"416-424","source":"Crossref","is-referenced-by-count":8,"title":["Treating great and small saphenous vein insufficiency with histoacryl                     in patients with symptomatic varicose veins and increased risk of                     surgery"],"prefix":"10.1024","volume":"47","author":[{"given":"Karel","family":"Novotn\u00fd","sequence":"first","affiliation":[{"name":"Department of Cardiology, 2nd Faculty of                     Medicine, Charles University, Prague and Motol University Hospital, Prague,                     Czech 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