{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T01:35:19Z","timestamp":1771637719201,"version":"3.50.1"},"reference-count":30,"publisher":"Hogrefe Publishing Group","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vasa"],"published-print":{"date-parts":[[2020,4,1]]},"abstract":"<jats:p> Summary: Background: Symptomatic peripheral arterial disease (intermittent claudication) is a major cause of disability and mobility loss in older men and women and thus has a significant negative impact on the patients\u2019 quality of life. Both surgical and endovascular revascularization procedures and noninvasive medical therapies, such as supervised training and drug treatment, can improve walking capacity. Cilostazol is the only drug having a class I (level of evidence A) recommendation for the treatment of intermittent claudication (IC). The aim of this study was to evaluate the effect of three-month cilostazol treatment on the health-related quality of life and on the lower limb functional capacity in patients with IC in the clinical practice. Patients and methods: The study was a multicenter, non-interventional trial, performed in Hungary in 2018. 812 PAD patients (Fontaine II stage, mean age: 67.17\u00a0years, male\/female: 58.25\/41.75\u00a0%) were enrolled, who received cilostazol (50 or 100\u00a0mg b.i.d.) for 3 months. 802 patients completed the study. Quality of life was evaluated with the EQ-5D-3L questionnaire functional capacity with the WELCH (Walking Estimated-Limitation Calculated by History) questionnaire. Pain-free and maximal walking distance, ankle-brachial index (ABI) were measured at baseline and after 3-month treatment. Results: Upon conclusion of the study, the EQ-5D-3L index improved (baseline: \u20130.46 \u00b1 0.22, 3rd month: \u20130.26 \u00b1 0.18; p &lt; 0.0001) and there was a significant increase in the WELCH score as well (19 \u00b1 14, 31 \u00b1 18; respectively, p &lt; 0.0001). Both pain-free and maximal walking distance improved significantly by 54.52\u00a0% (median: 53.85\u00a0%) and 42.5\u00a0% (median: 34.68\u00a0%); respectively (p &lt; 0.001). Adverse events occurred in 10 patients, 1 patient stopped cilostazol treatment because of side effects. Conclusions: Three months cilostazol treatment significantly improved quality of life and lower limb functional capacity in patients with intermittent claudication. The WELCH questionnaire is a useful tool for the evaluation of intermittent claudication treatment in the clinical practice. <\/jats:p>","DOI":"10.1024\/0301-1526\/a000845","type":"journal-article","created":{"date-parts":[[2020,1,27]],"date-time":"2020-01-27T09:01:02Z","timestamp":1580115662000},"page":"235-242","source":"Crossref","is-referenced-by-count":17,"title":["Simple assessment of quality of life and lower limb functional \t\t\t\t\tcapacity during cilostazol treatment \u2013 results of the SHort-tERm \t\t\t\t\tcIlostazol eFFicacy and quality of life (SHERIFF) study"],"prefix":"10.1024","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5577-6808","authenticated-orcid":true,"given":"Katalin","family":"Farkas","sequence":"first","affiliation":[{"name":"Department of Angiology, Szent Imre University \t\t\t\t\tTeaching Hospital, Budapest, 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