{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T05:19:33Z","timestamp":1773379173562,"version":"3.50.1"},"reference-count":27,"publisher":"Hogrefe Publishing Group","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vasa"],"published-print":{"date-parts":[[2021,2,1]]},"abstract":"<jats:p> Summary: Background: A recent meta-analysis of randomized controlled trials suggested an increased long-term mortality risk following femoropopliteal angioplasty using paclitaxel coated devices. To assess the long-term mortality after paclitaxel drug-coated (DCB) and uncoated balloon angioplasty (POBA) of femoropopliteal lesions in patients with ulcerations and gangrene in real world practice. Patients and methods: A retrospective mortality analysis of patients with at least 3-year follow-up who underwent balloon based endovascular therapy of femoropopliteal lesions was performed. Results: Overall 624 patients with femoropopliteal lesions were included in this study. Of those, 197 patients were treated with POBA without crossover to a paclitaxel coated device during follow-up and 427 patients with DCB angioplasty. Mean follow-up time was 33.3\u00a0\u00b1\u00a025.4 months. Mortality incidence was 81.7% (95% confidence interval [95% CI]: 76.1\u201386.8) after POBA and 59.0% (95% CI: 54.6\u201363.9) after DCB (p\u00a0&lt;\u00a00.001). Multivariate logistic regression analysis revealed type of treatment (POBA vs. DCB, (hazard ratio [HR]: 0.332, 95% CI: 0.215\u20130.514, p\u00a0&lt;\u00a00.001), age per year (HR: 1.065, 95% CI: 1.046\u20131.087, p\u00a0&lt;\u00a00.001), coronary heart disease (HR: 1.969, 95% CI: 1.323\u20132.930, p\u00a0=\u00a00.001), renal insufficiency (HR: 1.583, 95% CI: 1.079\u20132.323, p\u00a0=\u00a00.019), stroke (HR: 2.505, 95% CI: 1.431\u20134.384, p\u00a0=\u00a00.001) as predictors for all-cause mortality. In the subgroup excluding octogenarians, mortality predictors were type of treatment (HR: 0.463, 95% CI: 0.269\u20130.796, p\u00a0=\u00a00.005), age per year (HR: 1.035, 95% CI: 1.002\u20131.069, p\u00a0=\u00a00.038), coronary heart disease (HR: 2.082, 95% CI: 1.274\u20133.400, p\u00a0=\u00a00.003), stroke (HR: 2.203, 95% CI: 1.156\u20134.197, p\u00a0=\u00a00.016) and renal insufficiency (HR: 2.201, 95% CI: 1.357\u20133.571, p\u00a0&lt;\u00a00.001). Conclusions: This monocentric retrospective analysis showed no survival disadvantage for patients in Rutherford-Becker stage 5 after treatment with paclitaxel-coated balloons. <\/jats:p>","DOI":"10.1024\/0301-1526\/a000910","type":"journal-article","created":{"date-parts":[[2020,10,29]],"date-time":"2020-10-29T09:54:43Z","timestamp":1603965283000},"page":"132-138","source":"Crossref","is-referenced-by-count":7,"title":["Evaluation of mortality following paclitaxel drug-coated balloon angioplasty of femoropopliteal lesions in patients with ulcerations and gangrene \u2013 a single center experience"],"prefix":"10.1024","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1327-4241","authenticated-orcid":true,"given":"Tanja","family":"B\u00f6hme","sequence":"first","affiliation":[{"name":"Department of Cardiology and Angiology II, University Heart Center Freiburg-Bad Krozingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elias","family":"Noory","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Angiology II, University Heart Center Freiburg-Bad Krozingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrich","family":"Beschorner","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Angiology II, University Heart Center Freiburg-Bad Krozingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B\u00f6rries","family":"Jacques","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Angiology II, University Heart Center Freiburg-Bad Krozingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karlheinz","family":"B\u00fcrgelin","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Angiology II, University Heart Center Freiburg-Bad Krozingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roland","family":"Macharzina","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Angiology II, University Heart Center Freiburg-Bad Krozingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa-Marie","family":"Kuhn","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Angiology II, University Heart Center Freiburg-Bad Krozingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"N\u00fchrenberg","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Angiology II, University Heart Center Freiburg-Bad Krozingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franz-Josef","family":"Neumann","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Angiology II, University Heart Center Freiburg-Bad Krozingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Zeller","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Angiology II, University Heart Center Freiburg-Bad Krozingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"101","reference":[{"key":"c1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)61249-0"},{"key":"c2","doi-asserted-by":"publisher","DOI":"10.1016\/S1051-0443(91)72275-6"},{"key":"c3","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv006"},{"key":"c4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2010.02.009"},{"key":"c5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2006.12.037"},{"key":"c6","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.27635"},{"key":"c7","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.jacc.2018.10.002","volume":"73","author":"Bailey SR","year":"2019","journal-title":"J Am Coll Cardiol"},{"key":"c8","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.118.011245"},{"key":"c9","unstructured":"FDA, US. 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