{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T08:47:41Z","timestamp":1775638061982,"version":"3.50.1"},"reference-count":30,"publisher":"Hogrefe Publishing Group","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vasa"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p> Summary: Background: Sex-related differences may influence the outcome of endovascular revascularization (EVR) in patients with lower extremity arterial disease (LEAD) even under optimized healthcare supply. Patients and methods: LEAD patients who underwent EVR at the Department of Cardiology I \u2013 Coronary and Peripheral Vascular Disease, Heart Failure, University Hospital Muenster, Germany between 2014 and 2016 were included into the retrospective study. Detailed information on risk factors and co-morbidities, medication, LEAD related measures, and interventional parameters were assessed. Outcome defined as technical success rate, complications, and mortality was analyzed up to 12 months follow-up. Results: In total, 165 female and 437 male LEAD patients were included. Women and men presented with comparable severity of LEAD in terms of critical limb threatening ischemia (46.2%), wound status (34.9%), and amputation rate (9.6%, all n.s.) at index. Intake of platelet inhibitors (65.8% female vs. 70.0% male), oral anticoagulants (21.3% vs. 25.4%), and statins (65.6% vs. 76.0%) was observed less frequently in female patients. Against the background of high technical success (85%), in-hospital death (0.8%), severe adverse cardiac (MCE; 1.7%), and limb events (MALE; 6.1%) occurred at low rates in either sex. Adjusted long-term mortality was not affected by patients\u2019 sex (female HR 0.755; p=0.312). Conclusions: Despite critical LEAD stages in every second patient, EVR was performed safe with high technical success rates in female and male patients. Long-term outcomes were observed at comparatively low rates in both sexes at the specialized vascular center. During aftercare, supply with statin therapy turned out improvable particularly in female LEAD patients. <\/jats:p>","DOI":"10.1024\/0301-1526\/a000978","type":"journal-article","created":{"date-parts":[[2021,11,29]],"date-time":"2021-11-29T11:57:04Z","timestamp":1638187024000},"page":"29-36","source":"Crossref","is-referenced-by-count":9,"title":["Sex-related differences in outcome after endovascular \t\t\t\t\trevascularization for lower extremity artery disease"],"prefix":"10.1024","volume":"51","author":[{"given":"Henrike","family":"Barenbrock","sequence":"first","affiliation":[{"name":"Division of Vascular Medicine, Department of \t\t\t\t\tCardiology I, Coronary and Peripheral Vascular Disease, Heart Failure, \t\t\t\t\tUniversity Hospital Muenster, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jannik","family":"Feld","sequence":"additional","affiliation":[{"name":"Division of Vascular Medicine, Department of \t\t\t\t\tCardiology I, Coronary and Peripheral 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Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lena","family":"Makowski","sequence":"additional","affiliation":[{"name":"Division of Vascular Medicine, Department of \t\t\t\t\tCardiology I, Coronary and Peripheral Vascular Disease, Heart Failure, \t\t\t\t\tUniversity Hospital Muenster, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christiane M.","family":"Engelbertz","sequence":"additional","affiliation":[{"name":"Division of Vascular Medicine, Department of \t\t\t\t\tCardiology I, Coronary and Peripheral Vascular Disease, Heart Failure, \t\t\t\t\tUniversity Hospital Muenster, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Holger","family":"Reinecke","sequence":"additional","affiliation":[{"name":"Division of Vascular Medicine, Department of \t\t\t\t\tCardiology I, Coronary and Peripheral Vascular Disease, Heart Failure, \t\t\t\t\tUniversity Hospital Muenster, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nasser","family":"Malyar","sequence":"additional","affiliation":[{"name":"Division of Vascular Medicine, Department of \t\t\t\t\tCardiology I, Coronary and Peripheral Vascular Disease, Heart Failure, \t\t\t\t\tUniversity Hospital Muenster, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Freisinger","sequence":"additional","affiliation":[{"name":"Division of Vascular Medicine, Department of \t\t\t\t\tCardiology I, Coronary and Peripheral Vascular Disease, Heart Failure, \t\t\t\t\tUniversity Hospital Muenster, 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