{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T18:38:41Z","timestamp":1758393521075,"version":"3.40.5"},"reference-count":32,"publisher":"Hogrefe Publishing Group","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vasa"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:p> Summary: Background: Catheter-based thrombus removal (CBTR) reduces the risk of moderate to severe post-thrombotic syndrome (PTS) in patients with acute iliofemoral deep vein thrombosis (IF-DVT). However, the impact of concomitant popliteal DVT on clinical and duplex sonographic outcomes is unknown. Patients and methods: In this post-hoc analysis including the entire cohort of the randomized controlled BERNUTIFUL trial (48 patients), we compared clinical (incidence\/severity of PTS assessed by Villalta score and revised venous clinical severity scores, rVCSS), disease-specific quality-of-life (QOL, CIVIQ-20 survey) and duplex sonographic outcomes (patency, reflux, post-thrombotic lesions) at 12 months follow-up between patients with IF-DVT with and without concomitant popliteal DVT treated by CBTR. Results: Overall, 48 IF-DVT patients were included (48% men, median age of 50 years), of whom 17 (35%) presented with popliteal DVT. At baseline, patients with popliteal DVT were older, had a higher body mass index and more important leg swelling. At 12 months, freedom from PTS (93% vs 87%, P=0.17), median total Villalta score (1 vs 1.5; P=0.46), rVCSS (2 vs 1.5, P=0.5) and disease-specific QOL (24 points vs 24 points, P=0.72) were similar between patient with and without popliteal DVT, respectively. Duplex sonographic outcomes were similar, except for more frequent popliteal post-thrombotic lesions and reflux (P=0.02) in patients with popliteal DVT. Conclusions: Relevant clinical outcomes 1 year after successful CBTR were favorable, regardless of the presence or absence of concomitant popliteal DVT. However, post-thrombotic popliteal vein lesions and reflux are more frequent in IF-DVT patients with popliteal involvement. Their impact on long-term outcomes remains to be investigated. <\/jats:p>","DOI":"10.1024\/0301-1526\/a001017","type":"journal-article","created":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T06:11:52Z","timestamp":1656655912000},"page":"282-290","source":"Crossref","is-referenced-by-count":6,"title":["Impact of concomitant popliteal vein thrombosis in patients with \t\t\t\t\tacute iliofemoral deep vein thrombosis treated with endovascular early thrombus \t\t\t\t\tremoval"],"prefix":"10.1024","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4104-3280","authenticated-orcid":true,"given":"Vincent","family":"Frey","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, HFR Fribourg \t\t\t\t\t\u2013 Cantonal Hospital, Fribourg, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tim","family":"Sebastian","sequence":"additional","affiliation":[{"name":"Department of Angiology, University Hospital Zurich, 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