{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T09:10:02Z","timestamp":1746436202582,"version":"3.40.4"},"reference-count":38,"publisher":"Hogrefe Publishing Group","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vasa"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:p> Summary: Objective: Abdominal aortic aneurysm (AAA) is a permanent local dilation of the abdominal aorta developed by chronic local inflammation and elastin degradation. Trigonella foenum-graecum (fenugreek) has been reported to have anti-inflammatory properties. We hypothesized that fenugreek supplementation can inhibit AAA growth. Materials and methods: AAA was induced in male Sprague\u2013Dawley rats by intraluminal porcine pancreatic elastase infusion. The treatment by oral gavage was initiated post-operatively on day 1 and was administered daily (750\u00a0mg\/kg\/daily or 1500\u00a0mg\/kg\/daily or distilled water) for 27 days. AAA expansion was monitored weekly by ultrasound measurements in a blinded-to-treatment fashion; rats were euthanized 28 days after surgery. AAA cross-sections were examined histologically, where treatment allocation were blinded. Results: AAA developed in all three groups, yet there was no measured difference (p=0.104) in the maximal inner anterior-posterior abdominal aortic diameter on day 28 post-surgery between the control group (110% \u00b1 70%, n=11), the low-dose fenugreek treatment group (LDF, 105% \u00b1 68%, n=11), and the high-dose fenugreek treatment group (HDF, 153% \u00b1 96%, n=13). Additionally, assessments of elastin structure in the AAA wall using Miller\u2019s stain revealed disorganized and ruptured fibers, but no significant differences in the severity of damage or elastin content among the groups were noted. No significant differences were observed in the presence of infiltrating neutrophils (as indicated by myeloperoxidase-positive cells), macrophage infiltration (% CD68-positive area), or area of vascular smooth muscle cells (a-SMA stained cells), or media thickness across control low-dose, and high-dose treatment groups. Conclusions: Daily fenugreek administrations did not halt AAA progression in either low-dose (750 mg\/kg\/daily) or high-dose (1500 mg\/kg\/daily) groups when compared to controls. These results did not show any beneficial effects of fenugreek supplementation in the aneurysm wall, and therefore, we can not recommend fenugreek supplementation as a treatment for patients with growing AAAs. <\/jats:p>","DOI":"10.1024\/0301-1526\/a001185","type":"journal-article","created":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T12:16:44Z","timestamp":1741177004000},"page":"209-217","source":"Crossref","is-referenced-by-count":0,"title":["Daily fenugreek intake does not attenuate abdominal aortic aneurysm growth in rats"],"prefix":"10.1024","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1721-2408","authenticated-orcid":true,"given":"Egle","family":"Kavaliunaite","sequence":"first","affiliation":[{"name":"Cardiovascular and Renal Research Unit, Institute for Molecular Medicine, University of Southern Denmark, Odense, Denmark"},{"name":"Department of Cardiac, Thoracic and Vascular Surgery, Odense University Hospital (OUH), Odense, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9453-1141","authenticated-orcid":true,"given":"Thomas Emil","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology, Odense University Hospital, Odense, Denmark"},{"name":"Research Unit of Clinical Microbiology, Department of Clinical Research, University of Southern Denmark, Odense, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9536-4488","authenticated-orcid":true,"given":"Jes S.","family":"Lindholt","sequence":"additional","affiliation":[{"name":"Department of Cardiac, Thoracic and Vascular Surgery, Odense University Hospital (OUH), Odense, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2703-453X","authenticated-orcid":true,"given":"Jane","family":"Stubbe","sequence":"additional","affiliation":[{"name":"Cardiovascular and Renal Research Unit, Institute for Molecular Medicine, University of Southern Denmark, Odense, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"101","reference":[{"key":"c1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2018.09.020"},{"key":"c2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.121.315942"},{"key":"c3","doi-asserted-by":"publisher","DOI":"10.1177\/1538574408315205"},{"key":"c4","doi-asserted-by":"publisher","DOI":"10.2174\/157016111201140327165406"},{"key":"c5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2023.11.037"},{"key":"c6","doi-asserted-by":"publisher","DOI":"10.1586\/14779072.2015.1074861"},{"key":"c7","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.118.313187"},{"key":"c8","doi-asserted-by":"publisher","DOI":"10.3934\/mbe.2021076"},{"issue":"1","key":"c9","first-page":"20","volume":"8","author":"Basch E","year":"2003","journal-title":"Altern Med Rev"},{"key":"c10","doi-asserted-by":"publisher","DOI":"10.1007\/s40292-023-00565-6"},{"key":"c11","doi-asserted-by":"publisher","DOI":"10.4103\/0253-7613.186195"},{"key":"c12","doi-asserted-by":"publisher","DOI":"10.1080\/08923973.2023.2202298"},{"key":"c13","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2023.2221971"},{"key":"c14","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241813999"},{"key":"c15","unstructured":"Limiting AAA With Metformin (LIMIT) Trial. 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