{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T14:04:07Z","timestamp":1777903447714,"version":"3.51.4"},"reference-count":25,"publisher":"Hogrefe Publishing Group","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vasa"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:p> Summary: Background: Kidney transplantation (KT) has been shown to enhance the quality of life, be more cost-effective, and reduce mortality in dialysis patients. We aimed to study the impact of pre-existing diabetes mellitus (DM) and peripheral arterial disease (PAD) on cardiovascular outcomes and mortality after kidney transplantation (KT). Materials and methods: A secondary USRDS (United States Renal Data System) analysis was performed from 2006 to 2017 in adult patients who underwent KT. The primary outcome was 3-year all-cause mortality, and secondary outcomes were myocardial infarction (MI), cerebrovascular accident, gangrene\/limb ischemia, and graft failure. Adjusted hazard ratios were computed, and multivariate analysis was conducted. All p-values were 2-sided, and a value of &lt;0.05 was deemed to be statistically significant. Statistical analyses were performed using the SAS 9.4 software. Results: A total of 51,009 patients with kidney transplants met the study inclusion\/ exclusion criterion. Patients with both DM and PAD had the highest risk of mortality (15.3%, aHR 1.8, 1.6\u20132.0), followed by patients with PAD without DM (14.1%, aHR 1.6, 1.4\u20131.9), DM without PAD (9.9%, aHR 1.4, 1.3\u20132.6), and those without either DM or PAD (5.5%). MI was also higher in patients with DM and PAD (7.3%, aHR 1.8, 1.5\u20132.2), followed by DM alone (4.6%, aHR 1.58, 1.4\u20131.7), PAD alone (4.3%, aHR 1.14, 0.8\u20131.6), and no diabetes nor PAD (2.2%). Conclusions: In patients undergoing KT, those with pre-existing DM and\/ or PAD have a significantly higher all-cause mortality and risk of MI. <\/jats:p>","DOI":"10.1024\/0301-1526\/a001201","type":"journal-article","created":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T08:27:02Z","timestamp":1748420822000},"page":"235-241","source":"Crossref","is-referenced-by-count":2,"title":["Cardiovascular outcomes in kidney transplant patients with pre-existing peripheral arterial disease and diabetes mellitus"],"prefix":"10.1024","volume":"54","author":[{"given":"Mohinder R.","family":"Vindhyal","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine, The University of Kansas Medical Center, Kansas City, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-4089-895X","authenticated-orcid":true,"given":"Sahith","family":"Mandala","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Virginia Tech Carilion, Roanoke, Virginia, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6883-5686","authenticated-orcid":true,"given":"Wan-Chi","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, The University of Kansas Medical Center, Kansas City, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6880-8397","authenticated-orcid":true,"given":"Rhythm","family":"Vasudeva","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, The University of Kansas Medical Center, Kansas City, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4060-9561","authenticated-orcid":true,"given":"Suveenkrishna","family":"Pothuru","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, The University of Kansas Medical Center, Kansas City, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2136-4183","authenticated-orcid":true,"given":"Harsh","family":"Mehta","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, The University of Kansas Medical Center, Kansas City, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7920-2577","authenticated-orcid":true,"given":"Sania","family":"Jiwani","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, The University of Kansas Medical Center, Kansas City, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamal","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, The University of Kansas Medical Center, Kansas City, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"101","reference":[{"key":"c1","unstructured":"United States Renal Data System. 2022 USRDS Annual Data Report: Epidemiology of kidney disease in the United States. 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