{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T05:27:24Z","timestamp":1790141244129,"version":"4.0.1"},"reference-count":23,"publisher":"Hogrefe Publishing Group","license":[{"start":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T00:00:00Z","timestamp":1773187200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vasa"],"abstract":"<jats:p>Summary: Background: Data on volume changes after complex decongestive therapy (CDT) for leg lymphedema are sparse. This naturalistic prospective cohort study aimed to quantify the intraindividual changes of leg volume after comprehensive inpatient rehabilitation, focusing on intensive CDT, and to relate these changes to health-related quality of life (HRQOL). Patients and methods: Limb volume of patients with leg lymphedema (n = 101; 75 women) were measured between entry and discharge (3 weeks later) by the 4 cm measurement method according to Kuhnke and the Perometer\u00ae method. Changes were also expressed as standardised response means (SRM). The change on the Freiburg Quality of Life Assessment for lymphatic disorders, short version (FLQA-lk) total score was predicted using multivariate linear regression analysis with volume data adjusted for various confounders. Results: The overall mean volume decrease on the 4 cm\/Perometer\u00ae method for both legs combined was 1.94\/1.31 l for all patients, corresponding to SRMs of 1.04\/0.86. In the lymphedema-affected limbs, the decreases ranged between 1.03 and 1.40 l\/0.77 and 0.99 l (SRMs 0.70\u20131.72\/0.67\u20131.28). The total volume loss (4 cm) of both legs of all n = 101 patients correlated by 0.240 (bivariate, p = .010) and by 0.216 (multivariate, adjusted, p = .045). Conclusions: After multidisciplinary rehabilitation focusing on intensive CDT, moderate to large effects on reducing limb volume were observed. Volume reduction was positively associated with improvement in HRQOL.<\/jats:p>","DOI":"10.1024\/0301-1526\/a001268","type":"journal-article","created":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T06:20:32Z","timestamp":1773210032000},"source":"Crossref","is-referenced-by-count":2,"title":["Volume reduction in leg lymphedema after comprehensive inpatient rehabilitation"],"prefix":"10.1024","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3342-8591","authenticated-orcid":true,"given":"Felix","family":"Angst","sequence":"first","affiliation":[{"name":"Research Department, Rehaklinik Bad Zurzach, ZURZACH Care Group, Bad Zurzach, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Benz","sequence":"additional","affiliation":[{"name":"Research Department, Rehaklinik Bad Zurzach, ZURZACH Care Group, Bad Zurzach, Switzerland"},{"name":"Institute of Physiotherapy, School of Health Sciences, ZHAW Zurich University of Applied Sciences, Winterthur, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Lehmann","sequence":"additional","affiliation":[{"name":"Research Department, Rehaklinik Bad Zurzach, ZURZACH Care Group, Bad Zurzach, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter S.","family":"S\u00e1ndor","sequence":"additional","affiliation":[{"name":"Research Department, Rehaklinik Bad Zurzach, ZURZACH Care Group, Bad Zurzach, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Wagner","sequence":"additional","affiliation":[{"name":"Research Department, Rehaklinik Bad Zurzach, ZURZACH Care Group, Bad Zurzach, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"101","published-online":{"date-parts":[[2026,3,11]]},"reference":[{"issue":"1","key":"c1","first-page":"1","volume":"46","author":"International Society of Lymphology","year":"2013","journal-title":"Lymphology."},{"key":"c2","doi-asserted-by":"publisher","DOI":"10.1186\/s12955-020-01488-9"},{"key":"c3","volume-title":"Guideline for diagnostic and therapy of lymphedema","author":"German Association of Lymphology","year":"2017"},{"key":"c4","doi-asserted-by":"publisher","DOI":"10.1097\/PHM.0000000000000246"},{"key":"c5","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2023.06.001"},{"key":"c6","doi-asserted-by":"publisher","DOI":"10.1089\/lrb.2016.0056"},{"key":"c7","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2021.06.027"},{"key":"c8","doi-asserted-by":"publisher","DOI":"10.1080\/09593985.2016.1247935"},{"key":"c9","doi-asserted-by":"publisher","DOI":"10.5535\/arm.2015.39.3.347"},{"key":"c10","doi-asserted-by":"publisher","DOI":"10.2340\/1651-226X.2025.42560"},{"key":"c11","doi-asserted-by":"publisher","DOI":"10.3390\/healthcare7030101"},{"issue":"2","key":"c12","first-page":"67","volume":"4","author":"Kuhnke E","year":"1980","journal-title":"Z Lymphol."},{"key":"c13","doi-asserted-by":"publisher","DOI":"10.1016\/S1078-5884(96)80005-0"},{"key":"c14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1475-097X.2004.00577.x"},{"issue":"1","key":"c15","first-page":"26","volume":"40","author":"Deltombe T","year":"2007","journal-title":"Lymphology."},{"key":"c16","doi-asserted-by":"publisher","DOI":"10.1024\/0301-1526.34.1.31"},{"key":"c17","unstructured":"Cohen J. Statistical Power Analysis for the Behavioral Sciences. 2 New edition. Hillsdale, NJ: Taylor & Francis Inc, 1988. 400."},{"key":"c18","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-199007000-00008"},{"key":"c19","unstructured":"Benz T, Wagner S, Lehmann S, Sandor PS, Angst F. Health and quality of life in patients with lower limb lymphedema during the maintenance phase of complex decongestive therapy. Manuscript submitted for publication 2025."},{"key":"c20","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2017.09.003"},{"key":"c21","doi-asserted-by":"publisher","DOI":"10.1177\/1358836X0000500202"},{"issue":"3","key":"c22","first-page":"127","volume":"37","author":"Meijer RS","year":"2004","journal-title":"Lymphology."},{"key":"c23","doi-asserted-by":"publisher","DOI":"10.1097\/PHM.0b013e31815b6199"}],"container-title":["Vasa"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/econtent.hogrefe.com\/doi\/pdf\/10.1024\/0301-1526\/a001268","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T06:20:33Z","timestamp":1773210033000},"score":1,"resource":{"primary":{"URL":"https:\/\/econtent.hogrefe.com\/doi\/10.1024\/0301-1526\/a001268"}},"subtitle":["A naturalistic prospective cohort study"],"short-title":[],"issued":{"date-parts":[[2026,3,11]]},"references-count":23,"alternative-id":["10.1024\/0301-1526\/a001268"],"URL":"https:\/\/doi.org\/10.1024\/0301-1526\/a001268","relation":{},"ISSN":["0301-1526","1664-2872"],"issn-type":[{"value":"0301-1526","type":"print"},{"value":"1664-2872","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,11]]},"article-number":"0301-1526\/a001268"}}