{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T12:46:33Z","timestamp":1792673193754,"version":"4.5.0"},"reference-count":32,"publisher":"Hogrefe Publishing Group","license":[{"start":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:00:00Z","timestamp":1792627200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vasa"],"abstract":"<jats:p>Summary: Background: Peripheral artery disease (PAD) is associated with a high burden of cardiovascular and limb events, yet guideline-directed medical therapy remains suboptimal. The START-SIAPAV-PAD registry was designed to describe characteristics, management and clinical history of patients with PAD in Italy. Baseline characteristics and treatment are reported. Patients and methods: START-SIAPAV-PAD is a prospective, multicentre, observational registry enrolling consecutive adults with PAD managed at 20 Italian Vascular centres, starting in February 2023. Standardised electronic case-report forms collect demographics, risk factors, comorbidities, haemodynamic parameters, vascular anatomy, therapies. Follow-up is planned for a minimum of 3 years. PAD severity is classified according to the Leriche-Fontaine scale, and risk-factor targets follow the 2024 ESC guidelines. Results: The present analysis includes 517 patients (72.0% male; median age 71 years) with a high prevalence of hypertension (79.2%), dyslipidaemia (85.0%), diabetes (36.9%), smoking (96.1% current or former) and chronic kidney disease (21.2%). Nearly half reported a walking distance &lt;200 m, 77.5% had a resting ankle\u2013brachial index \u2264.80, and 17.2% presented with Leriche-Fontaine stage IV. Femoropopliteal disease was most frequent (69.8%), with multilevel involvement in 43.4%. Previous revascularisation was common, major amputation was rare. LDL cholesterol target (&lt;55mg dL) was achieved in 27.9% of patients despite lipid-lowering therapy in 82.1%. Dual pathway inhibition, advanced lipid-lowering therapies, supervised exercise and structured smoking-cessation programmes were insufficiently adopted. Conclusions: In a population with advanced PAD and multiple risk factors we observed a substantial gap between guideline recommendations and real-world practice. Longitudinal follow-up will assess outcomes and opportunities to improve PAD management.<\/jats:p>","DOI":"10.1024\/0301-1526\/a001310","type":"journal-article","created":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T12:07:55Z","timestamp":1792670875000},"source":"Crossref","is-referenced-by-count":0,"title":["The START-SIAPAV-PAD Registry \u2013 Rationale, study design, and baseline characteristics of an ongoing Italian multicentre registry"],"prefix":"10.1024","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2558-1003","authenticated-orcid":true,"given":"Adriana","family":"Vison\u00e0","sequence":"first","affiliation":[{"name":"Outpatient department and healthcare services for external patients, Ospedale Riabilitativo di Alta Specializzazione (ORAS), Treviso, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corrado","family":"Amato","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Angiology Unit, University of Palermo, Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Biscetti","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine and Surgery, Catholic University of the Sacred Heart, Rome, Italy"},{"name":"UOC of Cardiovascular Internal Medicine, Department of Cardiovascular Sciences, A. 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