{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:18:18Z","timestamp":1760188698338},"reference-count":0,"publisher":"Hogrefe Publishing Group","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vasa"],"published-print":{"date-parts":[[2002,8,1]]},"abstract":"<jats:p> Backround: Ischemic ulcers are usually found above the lateral, and venous stasis ulcers at the medial malleoli. Leg ulcers occur in at least 25% of sickle cell disease (SSD) patients in clinic populations, usually in the malleolar region. The function of the large leg veins in most SSD patients is unimpaired. Patients and methods: We determined leg ulcer location in 41 sickle cell anemia (SS), and 4 sickle-b0 thalassemic patients with longstanding chronic and\/or recurrent leg ulceration, and reviewed published reports of leg ulcers in hereditary spherocytosis and thalassemias. Results: Of the 57 legs of the 45 SSD patients with only 1 ulcer, 42 (74%) were medial and 15 lateral. The difference was significant (p &lt; 0.001). Of patients with only a single ulcer, 22 were medial and 4 lateral. Of 15 reported patients with leg ulcers related to spherocytosis or thalassemia, 20\/24 (83%) ulcers were medial. Conclusions: The medial malleoli are the most common site of leg ulceration in SSD and in other chronic hemolytic anemias. This suggests that stasis may play a role in the leg ulceration associated with chronic hemolytic anemia. <\/jats:p>","DOI":"10.1024\/0301-1526.31.3.191","type":"journal-article","created":{"date-parts":[[2006,1,31]],"date-time":"2006-01-31T12:26:06Z","timestamp":1138710366000},"page":"191-193","source":"Crossref","is-referenced-by-count":15,"title":["Pr\u00e4dilektion des Malleolus medialis beim mit h\u00e4molytischer An\u00e4mie assoziierten Ulcus cruris"],"prefix":"10.1024","volume":"31","author":[{"family":"Sawhney","sequence":"first","affiliation":[{"name":"Division of Hematology-Oncology, Department of Medicine, Health Sciences Center at Brooklyn, State University of New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Weedon","sequence":"additional","affiliation":[{"name":"Department of Computer Science, Health Sciences Center at Brooklyn, State University of New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Gillette","sequence":"additional","affiliation":[{"name":"Division of Hematology-Oncology, Department of Medicine, Health Sciences Center at Brooklyn, State University of New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Solomon","sequence":"additional","affiliation":[{"name":"Division of Hematology-Oncology, Department of Medicine, Health Sciences Center at Brooklyn, State University of New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Braverman","sequence":"additional","affiliation":[{"name":"Division of Hematology-Oncology, Department of Medicine, Health Sciences Center at Brooklyn, State University of New York"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"101","container-title":["Vasa"],"original-title":[],"language":"de","link":[{"URL":"https:\/\/econtent.hogrefe.com\/doi\/pdf\/10.1024\/0301-1526.31.3.191","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,8]],"date-time":"2022-05-08T09:53:32Z","timestamp":1652003612000},"score":1,"resource":{"primary":{"URL":"https:\/\/econtent.hogrefe.com\/doi\/10.1024\/0301-1526.31.3.191"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,8,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2002,8,1]]}},"alternative-id":["10.1024\/0301-1526.31.3.191"],"URL":"https:\/\/doi.org\/10.1024\/0301-1526.31.3.191","relation":{},"ISSN":["0301-1526","1664-2872"],"issn-type":[{"value":"0301-1526","type":"print"},{"value":"1664-2872","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,8,1]]}}}