{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T17:16:14Z","timestamp":1694625374543},"reference-count":0,"publisher":"Hogrefe Publishing Group","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vasa"],"published-print":{"date-parts":[[2005,2,1]]},"abstract":"<jats:p> Thrombocytosis is either caused by a reactive process (secondary thrombocytosis) or by a clonal bone marrow disorder. The latter category includes essential thrombocythemia with bleedings and thrombotic complications as major causes of illness and death in this patients. We describe a 43-year-old man with a 6 months history of acroparesthesia in his toes. Half a year after onset of these symptoms, he noticed a bluish discoloration of digit V of his left foot. On first presentation physical examination revealed a bluish discoloration of all toes and a cold and blue digit V of the left foot. Peripheral pulses were all palpable, normal ankle systolic pressure measurements and normal pulse volume recordings except for digit V of the left foot were found. Laboratory tests revealed thrombocytosis of 800 000\/microliter. On treatment with acetylsalicylacid, prostanoids intravenously and low molecular weight heparin, the patient became asymptomatic and pulse volume recording of digit V was normalized. After exclusion of cardial or vascular sources of embolism by utrasonography bone marrow aspirate and biopsy supported the diagnosis of essential thrombocythemia. <\/jats:p>","DOI":"10.1024\/0301-1526.34.1.53","type":"journal-article","created":{"date-parts":[[2006,1,24]],"date-time":"2006-01-24T14:18:37Z","timestamp":1138112317000},"page":"53-56","source":"Crossref","is-referenced-by-count":0,"title":["Acroparesthesia and acral arterial occlusions as first manifestations of essential thrombocythemia"],"prefix":"10.1024","volume":"34","author":[{"family":"Husmann","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Divisions of Angiology, University Hospital Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Schenk Romer","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Divisions of Angiology, University Hospital Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Amann-Vesti","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Divisions of Angiology University Hospital Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Spada","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Divisions of Hematology University Hospital Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Koppensteiner","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Divisions of Angiology University Hospital Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"101","container-title":["Vasa"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/econtent.hogrefe.com\/doi\/pdf\/10.1024\/0301-1526.34.1.53","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,8]],"date-time":"2022-05-08T10:07:22Z","timestamp":1652004442000},"score":1,"resource":{"primary":{"URL":"https:\/\/econtent.hogrefe.com\/doi\/10.1024\/0301-1526.34.1.53"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,2,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2005,2,1]]}},"alternative-id":["10.1024\/0301-1526.34.1.53"],"URL":"https:\/\/doi.org\/10.1024\/0301-1526.34.1.53","relation":{},"ISSN":["0301-1526","1664-2872"],"issn-type":[{"value":"0301-1526","type":"print"},{"value":"1664-2872","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,2,1]]}}}