{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T17:16:03Z","timestamp":1694625363938},"reference-count":0,"publisher":"Hogrefe Publishing Group","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Praxis"],"published-print":{"date-parts":[[2002,1,1]]},"abstract":"<jats:p> Une patiente \u00e2g\u00e9e de 48 ans en bon \u00e9tat g\u00e9n\u00e9ral est adress\u00e9e pour investigation d'une valeur de Quick abaiss\u00e9e ainsi que d'une prolongation du temps de saignement en pr\u00e9sence d'un agrandissement des ganglions lymphatiques cervicaux et d'une dyscrasie plasmocytaire monoclonale connue. Les examens de laboratoire ont mis en \u00e9vidence, en plus d'une valeur de Quick nettement abaiss\u00e9e, une augmentation partielle, du temps de thromboplastine partielle, et un abaissement des facteurs VII et X en pr\u00e9sence d'une paraprot\u00e9in\u00e9mie \u00e0 cha\u00eenes l\u00e9g\u00e8res. L'analyse de la biopsie de la moelle osseuse permet de poser le diagnostic d'immunocytome en pr\u00e9sence d'une amylo\u00efdose. Une chimioth\u00e9rapie a \u00e9t\u00e9 effectu\u00e9e dans l'espoir d'influencer de fa\u00e7on favorable les troubles de la coagulation. Cela a provoqu\u00e9 cependant des complications s\u00e9v\u00e8res sous forme de saignement. Les investigations suppl\u00e9mentaires de la crase sanguine ont permis de diagnostiquer finalement un d\u00e9ficit en facteurs VII et X associ\u00e9 \u00e0 une amylo\u00efdose, une maladie de von Willebrand acquise ainsi qu'une coagulopathie de type lupus \u00e9ryth\u00e9mateux. Une substitution de complexes des facteurs VII et von Willebrand avec une chimioth\u00e9rapie a permis de stabiliser la patiente durant de nombreuses ann\u00e9es jusqu'\u00e0 son d\u00e9c\u00e8s des suites d'une pancr\u00e9atite aigu\u00eb associ\u00e9e \u00e0 une amylo\u00efdose. <\/jats:p>","DOI":"10.1024\/0369-8394.91.4.112","type":"journal-article","created":{"date-parts":[[2006,1,31]],"date-time":"2006-01-31T12:03:05Z","timestamp":1138708985000},"page":"112-118","source":"Crossref","is-referenced-by-count":1,"title":["Rezidivierende Spontanblutungen bei einer Patientin mit Leichtketten-Immunozytom"],"prefix":"10.1024","volume":"91","author":[{"family":"Neuhaus","sequence":"first","affiliation":[{"name":"Medizinische Universit\u00e4ts-Poliklinik Bonn"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"P\u00f6tzsch","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Experimentelle H\u00e4matologie und Transfusionsmedizin der Universit\u00e4t Bonn"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Ko","sequence":"additional","affiliation":[{"name":"Medizinische Universit\u00e4ts-Poliklinik Bonn"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"K\u00f6hler","sequence":"additional","affiliation":[{"name":"Pathologisches Institut der Universit\u00e4t Freiburg"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Brackmann","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Experimentelle H\u00e4matologie und Transfusionsmedizin der Universit\u00e4t Bonn"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Vetter","sequence":"additional","affiliation":[{"name":"Medizinische Universit\u00e4ts-Poliklinik Bonn"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"101","container-title":["Praxis"],"original-title":[],"language":"de","link":[{"URL":"https:\/\/econtent.hogrefe.com\/doi\/pdf\/10.1024\/0369-8394.91.4.112","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,8]],"date-time":"2022-05-08T11:13:18Z","timestamp":1652008398000},"score":1,"resource":{"primary":{"URL":"https:\/\/econtent.hogrefe.com\/doi\/10.1024\/0369-8394.91.4.112"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,1,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2002,1,1]]}},"alternative-id":["10.1024\/0369-8394.91.4.112"],"URL":"https:\/\/doi.org\/10.1024\/0369-8394.91.4.112","relation":{},"ISSN":["1661-8157","1661-8165"],"issn-type":[{"value":"1661-8157","type":"print"},{"value":"1661-8165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,1,1]]}}}