{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T17:16:38Z","timestamp":1694625398590},"reference-count":0,"publisher":"Hogrefe Publishing Group","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Praxis"],"published-print":{"date-parts":[[2002,2,1]]},"abstract":"<jats:p> La st\u00e9atose h\u00e9patique aigu\u00eb de la grossesse est une maladie rare mais dont l'\u00e9volution peut \u00eatre l\u00e9tale si elle est m\u00e9connue. Sa pathogen\u00e8se n'a pas encore \u00e9t\u00e9 compl\u00e8tement \u00e9claircie jusqu'\u00e0 ce jour. Il existe cependant des indices que certains cas pourraient \u00eatre associ\u00e9s \u00e0 un d\u00e9ficit g\u00e9n\u00e9tique de la b\u00e9ta-oxydation des acides gras. D'autres facteurs pr\u00e9disposant sont la primiparit\u00e9, une grossesse avec plusieurs foetus, un foetus de sexe m\u00e2le, et une pr\u00e9-\u00e9clampsie. La pr\u00e9sentation clinique et les modifications de laboratoire sont souvent asp\u00e9cifiques. Le stade pr\u00e9coce est caract\u00e9ris\u00e9 par une augmentation des transaminases. Une biopsie h\u00e9patique permet d'\u00e9tablir le diagnostic et met en \u00e9vidence de fa\u00e7on typique une st\u00e9atose h\u00e9patique microv\u00e9siculaire centrolobulaire. Le diagnostic diff\u00e9rentiel comprend le syndrome HELLP, la cholestase de la grossesse, la pr\u00e9-\u00e9clampsie et les h\u00e9patites virales ou m\u00e9dicamenteuses. Si elle n'est pas trait\u00e9e, elle peut \u00e9voluer jusqu'au tableau clinique complet d'une insuffisance h\u00e9patique avec troubles de la coagulation et enc\u00e9phalopathie. Ce travail, illustr\u00e9 par deux cas, pr\u00e9sente le tableau clinique et histopathologique de la st\u00e9atose h\u00e9patique aigu\u00eb de la grossesse ainsi que le diagnostic diff\u00e9rentiel et l'approche th\u00e9rapeutique. <\/jats:p>","DOI":"10.1024\/0369-8394.91.7.267","type":"journal-article","created":{"date-parts":[[2006,1,31]],"date-time":"2006-01-31T12:03:56Z","timestamp":1138709036000},"page":"267-273","source":"Crossref","is-referenced-by-count":0,"title":["Akute Schwangerschaftsfettleber: Klinischer und histopathologischer Verlauf"],"prefix":"10.1024","volume":"91","author":[{"family":"Wildi","sequence":"first","affiliation":[{"name":"Departement f\u00fcr Innere Medizin, Abteilung f\u00fcr Gastroenterologie, Stadtspital Triemli"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Reich","sequence":"additional","affiliation":[{"name":"Medizinische Klinik, Kantonsspital Frauenfeld"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Flury","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Pathologie, Kantonsspital Winterthur"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Lauper","sequence":"additional","affiliation":[{"name":"Departement f\u00fcr Geburtshilfe, Universit\u00e4tsspital Z\u00fcrich"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Risti","sequence":"additional","affiliation":[{"name":"Medizinische Klinik, Spital Limmattal Schlieren"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"M\u00fcllhaupt","sequence":"additional","affiliation":[{"name":"Departement f\u00fcr Innere Medizin, Abteilung f\u00fcr Gastroenterologie, Universit\u00e4tsspital Z\u00fcrich"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Meyenberger","sequence":"additional","affiliation":[{"name":"Departement f\u00fcr Innere Medizin, Fachbereich Gastroenterologie, Kantonsspital St.Gallen"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"101","container-title":["Praxis"],"original-title":[],"language":"de","link":[{"URL":"https:\/\/econtent.hogrefe.com\/doi\/pdf\/10.1024\/0369-8394.91.7.267","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,8]],"date-time":"2022-05-08T11:07:18Z","timestamp":1652008038000},"score":1,"resource":{"primary":{"URL":"https:\/\/econtent.hogrefe.com\/doi\/10.1024\/0369-8394.91.7.267"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,2,1]]},"references-count":0,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2002,2,1]]}},"alternative-id":["10.1024\/0369-8394.91.7.267"],"URL":"https:\/\/doi.org\/10.1024\/0369-8394.91.7.267","relation":{},"ISSN":["1661-8157","1661-8165"],"issn-type":[{"value":"1661-8157","type":"print"},{"value":"1661-8165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,2,1]]}}}