{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T17:16:54Z","timestamp":1694625414327},"reference-count":0,"publisher":"Hogrefe Publishing Group","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Praxis"],"published-print":{"date-parts":[[2003,1,1]]},"abstract":"<jats:p> Les aminoglycosides sont les antibiotiques de premier choix en cas d'infections s\u00e9v\u00e8res \u00e0 gram n\u00e9gatif. Les effets secondaires toxiques, particuli\u00e8rement la n\u00e9phrotoxicit\u00e9 et l'ototoxicit\u00e9, limitent leur utilisation. Les antibiotiques de ce groupe qui ont \u00e9t\u00e9 d\u00e9velopp\u00e9s plus tard sont certes moins ototoxiques mais peuvent \u00e9galement provoquer \u00e0 hautes doses des l\u00e9sions de l'oreille interne. Ce travail pr\u00e9sente les effets morphologiques, histochimiques et \u00e9lectrophysiologiques de ce groupe d'antibiotiques sur les syst\u00e8mes auditif et vestibulaire et les m\u00e9thodes qui permettent de mettre en \u00e9vidence une \u00e9ventuelle ototoxicit\u00e9 clinique. Gr\u00e2ce \u00e0 l'am\u00e9lioration des techniques de contr\u00f4le, il est possible de r\u00e9duire de fa\u00e7on importante le risque de toxicit\u00e9. Les recommandations concernant la pr\u00e9vention et la prise en charge des patients avec des troubles de l'ou\u00efe ou de l'\u00e9quilibre sont r\u00e9sum\u00e9es. <\/jats:p>","DOI":"10.1024\/0369-8394.92.4.127","type":"journal-article","created":{"date-parts":[[2006,1,31]],"date-time":"2006-01-31T12:07:03Z","timestamp":1138709223000},"page":"127-133","source":"Crossref","is-referenced-by-count":2,"title":["Ototoxizit\u00e4t von Aminoglykosidantibiotika"],"prefix":"10.1024","volume":"92","author":[{"family":"Reiss","sequence":"first","affiliation":[{"name":"Klinik f\u00fcr Hals-Nasen-Ohrenheilkunde, St\u00e4dtisches Klinikum G\u00f6rlitz"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Reiss","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Neurochirurgie Universit\u00e4tsklinikum Dresden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"101","container-title":["Praxis"],"original-title":[],"language":"de","link":[{"URL":"https:\/\/econtent.hogrefe.com\/doi\/pdf\/10.1024\/0369-8394.92.4.127","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,8]],"date-time":"2022-05-08T11:17:34Z","timestamp":1652008654000},"score":1,"resource":{"primary":{"URL":"https:\/\/econtent.hogrefe.com\/doi\/10.1024\/0369-8394.92.4.127"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,1,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2003,1,1]]}},"alternative-id":["10.1024\/0369-8394.92.4.127"],"URL":"https:\/\/doi.org\/10.1024\/0369-8394.92.4.127","relation":{},"ISSN":["1661-8157","1661-8165"],"issn-type":[{"value":"1661-8157","type":"print"},{"value":"1661-8165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,1,1]]}}}