{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,2,15]],"date-time":"2024-02-15T18:00:43Z","timestamp":1708020043170},"reference-count":0,"publisher":"Hogrefe Publishing Group","issue":"41","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Praxis"],"published-print":{"date-parts":[[2003,10,1]]},"abstract":"<jats:p> Nous pr\u00e9sentons le cas d'un jeune patient toxicomane qui a pr\u00e9sent\u00e9 un arr\u00eat cardio-respiratoire attribu\u00e9 \u00e0 des troubles du rythme ventriculaire de type torsade de pointe. Apr\u00e8s exclusion des causes habituelles associ\u00e9es \u00e0 ce trouble du rythme, nous avons retenu que la prise de hautes doses de m\u00e9thadone \u00e9tait responsable de ces torsades de pointe. La m\u00e9thadone peut provoquer des torsades de pointe par deux m\u00e9canismes: un allongement du QT sur bradycardie ou un prolongement du potentiel d'action du myocarde. Lors de prescription de m\u00e9thadone, il faut \u00e9viter d'associer d'autres m\u00e9dicaments inhibant l'iso-enzyme CYP3A4 du cytochrome P450, et, si des hautes doses sont n\u00e9cessaires, proc\u00e9der \u00e0 des contr\u00f4les \u00e9lectrocardiographiques. <\/jats:p>","DOI":"10.1024\/0369-8394.92.41.1748","type":"journal-article","created":{"date-parts":[[2006,1,31]],"date-time":"2006-01-31T12:09:30Z","timestamp":1138709370000},"page":"1748-1750","source":"Crossref","is-referenced-by-count":5,"title":["Torsade de pointe:  un effet secondaire grave et m\u00e9connu chez le toxicomane sous m\u00e9thadone"],"prefix":"10.1024","volume":"92","author":[{"family":"Vodoz","sequence":"first","affiliation":[{"name":"D\u00e9partement de M\u00e9decine, CHUV, Lausanne"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Jaquier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Lamy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"101","container-title":["Praxis"],"original-title":[],"language":"fr","link":[{"URL":"https:\/\/econtent.hogrefe.com\/doi\/pdf\/10.1024\/0369-8394.92.41.1748","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,8]],"date-time":"2022-05-08T11:21:08Z","timestamp":1652008868000},"score":1,"resource":{"primary":{"URL":"https:\/\/econtent.hogrefe.com\/doi\/10.1024\/0369-8394.92.41.1748"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,10,1]]},"references-count":0,"journal-issue":{"issue":"41","published-print":{"date-parts":[[2003,10,1]]}},"alternative-id":["10.1024\/0369-8394.92.41.1748"],"URL":"https:\/\/doi.org\/10.1024\/0369-8394.92.41.1748","relation":{},"ISSN":["1661-8157","1661-8165"],"issn-type":[{"value":"1661-8157","type":"print"},{"value":"1661-8165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,10,1]]}}}