{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T21:18:07Z","timestamp":1790543887610,"version":"4.1.0"},"reference-count":0,"publisher":"Hogrefe Publishing Group","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Praxis"],"published-print":{"date-parts":[[2004,2,1]]},"abstract":"<jats:p> Depuis environ 20 ans, plusieurs \u00e9tudes observationnelles ont sugg\u00e9r\u00e9 que le traitement hormonal substitutif (THS) r\u00e9duisait le risque de fractures, augmentait la qualit\u00e9 de vie et prot\u00e9geait contre les maladies cardiovasculaires. Le THS a \u00e9t\u00e9 largement prescrit pour ces indications. Toutefois toutes ces \u00e9vidences \u00e9taient bas\u00e9es sur des \u00e9tudes susceptibles de pr\u00e9senter de nombreux biais. D\u00e8s le d\u00e9but 1990, plusieurs \u00e9tudes randomis\u00e9es \u00e0 large \u00e9chelle ont \u00e9t\u00e9 initi\u00e9es. L'\u00e9tude la plus large (Women Health Initiative) a \u00e9t\u00e9 arr\u00eat\u00e9e pr\u00e9matur\u00e9ment (Seul le groupe THS combin\u00e9) du fait d'un rapport d\u00e9favorable entre les b\u00e9n\u00e9fices du traitement par rapport aux d\u00e9savantages. Les r\u00e9sultats de ces \u00e9tudes ont \u00e9t\u00e9 largement repris dans les media et ont d\u00e9stabilis\u00e9 plus d'une patiente et d'un m\u00e9decin. La soci\u00e9t\u00e9 Suisse de m\u00e9nopause a \u00e9mis une s\u00e9rie de directives ayant pour but de pr\u00e9ciser les indications aux THS. <\/jats:p>","DOI":"10.1024\/0369-8394.93.9.315","type":"journal-article","created":{"date-parts":[[2006,1,31]],"date-time":"2006-01-31T12:10:25Z","timestamp":1138709425000},"page":"315-320","source":"Crossref","is-referenced-by-count":1,"title":["Pr\u00e9vention de l'ost\u00e9oporose postm\u00e9nopausique par traitement hormonal substitutif: les risques sont-ils encore acceptables?"],"prefix":"10.1024","volume":"93","author":[{"family":"Wirthner","sequence":"first","affiliation":[{"name":"D\u00e9partement de gyn\u00e9cologie et obst\u00e9trique, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Cornuz","sequence":"additional","affiliation":[{"name":"Service de m\u00e9decine A et Centre d'\u00e9pid\u00e9miologie clinique, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Lamy","sequence":"additional","affiliation":[{"name":"Consultation d'ost\u00e9oporose et du m\u00e9tabolisme phosphocalcique, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"101","container-title":["Praxis"],"original-title":[],"language":"fr","link":[{"URL":"https:\/\/econtent.hogrefe.com\/doi\/pdf\/10.1024\/0369-8394.93.9.315","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,8]],"date-time":"2022-05-08T10:42:54Z","timestamp":1652006574000},"score":1,"resource":{"primary":{"URL":"https:\/\/econtent.hogrefe.com\/doi\/10.1024\/0369-8394.93.9.315"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,2,1]]},"references-count":0,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2004,2,1]]}},"alternative-id":["10.1024\/0369-8394.93.9.315"],"URL":"https:\/\/doi.org\/10.1024\/0369-8394.93.9.315","relation":{},"ISSN":["1661-8157","1661-8165"],"issn-type":[{"value":"1661-8157","type":"print"},{"value":"1661-8165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,2,1]]}}}