{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T21:19:38Z","timestamp":1700601578236},"reference-count":81,"publisher":"Hogrefe Publishing Group","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Zeitschrift f\u00fcr Kinder- und Jugendpsychiatrie und Psychotherapie"],"published-print":{"date-parts":[[2010,1]]},"abstract":"<jats:p> Fragestellung: Fallberichte von sieben Patienten mit Ticst\u00f6rungen mit einer Krankheitsdauer von mindestens zwei Jahren sollen Hinweise zur Wirksamkeit des partiellen Dopamin-Agonisten, Aripiprazol, geben, welches sich in der Behandlung von Ticst\u00f6rungen als wirksam und gut vertr\u00e4glich erwiesen hat. Methodik: F\u00fcnf Patienten mit einem Tourette-Syndrom (TS) und zwei mit chronisch motorischer Ticst\u00f6rung (Alter 8;7\u201318;1 Jahre), bei denen zuvor eingesetzte Neuroleptika ungen\u00fcgend wirksam waren oder wegen nicht tolerierbarer Nebenwirkungen abgesetzt werden mussten, wurden mindestens acht Wochen lang mit Aripiprazol behandelt. Vor und nach der Behandlung beantworteten die Eltern der Patienten das Ausma\u00df der vokalen und motorischen Ticsymptomst\u00e4rke auf der Yale-Tourette-Syndrom-Symptomliste. Ergebnisse: Innerhalb des Beobachtungszeitraums kam es zu einem deutlichen R\u00fcckgang der motorischen Ticsymptomatik um 66 % sowie zu einem R\u00fcckgang der vokalen Ticsymptomst\u00e4rke um 26 %, bei einer mittleren Tagesdosis von 14.3 mg (min. 5 mg, max. 30 mg). Symptome einer komorbiden Aufmerksamkeitsdefizit-St\u00f6rung sowie einer Zwangserkrankung wurden durch die Behandlung nicht wesentlich beeinflusst. W\u00e4hrend der Behandlung traten leichte Nebenwirkungen wie Bauchschmerzen, M\u00fcdigkeit und Weinerlichkeit auf. Behandlungsabbr\u00fcche wurden nicht beobachtet. Schlussfolgerungen: Aripiprazol stellt wom\u00f6glich eine wirkungsvolle und gut vertr\u00e4gliche, nebenwirkungsarme Alternative zur bisher \u00fcblichen neuroleptischen Behandlung von Ticst\u00f6rungen dar. Die Wirksamkeit, insbesondere im Hinblick auf Komorbidit\u00e4ten, sollte in klinisch kontrollierten Studien verifiziert werden. <\/jats:p>","DOI":"10.1024\/1422-4917\/a000049","type":"journal-article","created":{"date-parts":[[2010,7,9]],"date-time":"2010-07-09T03:10:18Z","timestamp":1278645018000},"page":"291-298","source":"Crossref","is-referenced-by-count":4,"title":["Aripiprazol"],"prefix":"10.1024","volume":"38","author":[{"given":"Jan","family":"Fr\u00f6lich","sequence":"first","affiliation":[{"name":"Zentralinstitut f\u00fcr Seelische Gesundheit, Mannheim"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martina","family":"Starck","sequence":"additional","affiliation":[{"name":"Zentralinstitut f\u00fcr Seelische Gesundheit, Mannheim"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tobias","family":"Banaschewski","sequence":"additional","affiliation":[{"name":"Zentralinstitut f\u00fcr Seelische Gesundheit, Mannheim"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerd","family":"Lehmkuhl","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Psychiatrie und Psychotherapie des Kindes \u2013 und Jugendalters der Universit\u00e4t zu K\u00f6ln"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"101","reference":[{"key":"c1","doi-asserted-by":"publisher","DOI":"10.1007\/s00787-007-1002-8"},{"key":"c2","doi-asserted-by":"publisher","DOI":"10.1024\/1422-4917.31.3.203"},{"key":"c3","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.161.7.1307"},{"key":"c4","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1C297"},{"key":"c5","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v62n0111"},{"key":"c6","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.145.5.621"},{"key":"c7","doi-asserted-by":"publisher","DOI":"10.1080\/15622970500474770"},{"key":"c8","doi-asserted-by":"publisher","DOI":"10.1089\/cap.2007.061"},{"key":"c9","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v62n0412"},{"key":"c10","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3999(02)00584-6"},{"key":"c11","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-199401000-00002"},{"key":"c12","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v66n0107"},{"key":"c13","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.161.3.414"},{"key":"c14","doi-asserted-by":"publisher","DOI":"10.1002\/hup.798"},{"key":"c15","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.162.3.625"},{"key":"c16","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-2918(04)90066-5"},{"key":"c17","volume-title":"Internationale Klassifikation psychischer St\u00f6rungen: ICD-10 Kapitel V (F). 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