{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T23:02:46Z","timestamp":1777590166676,"version":"3.51.4"},"reference-count":46,"publisher":"Hogrefe Publishing Group","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Zeitschrift f\u00fcr Kinder- und Jugendpsychiatrie und Psychotherapie"],"published-print":{"date-parts":[[2011,5]]},"abstract":"<jats:p> Das Gilles de la Tourette Syndrom (GTS) ist durch fluktuierend auftretende motorische und vokale Tics gekennzeichnet. Oft geht Tics ein Vorgef\u00fchl voraus, das teils als \u00abDrang\u00bb, teils als verst\u00e4rkt wahrgenommene K\u00f6rperempfindungen beschrieben wird. Sie wurden als treibende Kraft der Tics interpretiert. Allerdings liegt nicht immer eine eindeutige Abfolge von Vorgef\u00fchl und Tic vor. Auch entwickeln sich Vorgef\u00fchle zumeist erst nach dem 10. Lebensjahr und damit Jahre nach dem Auftreten erster Tics. Insofern ist die Beziehung zwischen sensorischen und motorischen Ph\u00e4nomenen beim GTS unklar. Die vorliegende Arbeit gibt einen \u00dcberblick \u00fcber den aktuellen Wissensstand. Bisherige neurophysiologische Untersuchungen sprechen f\u00fcr eine gest\u00f6rte senso-motorische Integration beim GTS. Strukturelle Untersuchungen mittels MRT zeigten einerseits eine Ausd\u00fcnnung des senso-motorischen Kortex bei Kindern und Jugendlichen mit GTS, andererseits eine Zunahme der fraktionellen Anisotropie als Ma\u00df der Gerichtetheit von Faserb\u00fcndeln in der wei\u00dfen Substanz unterhalb des Gyrus post- und pr\u00e4centralis bei Erwachsenen mit GTS. Diese Daten deuten auf die Rolle von Reifungsst\u00f6rungen und Reorganisationsvorg\u00e4ngen im somato-sensorischen System beim GTS hin. Multimodale Untersuchungen mit struktureller und funktioneller Bildgebung und elektrophysiologischen Methoden in klinisch gut charakterisierten GTS Subgruppen k\u00f6nnten in Zukunft zu einem besseren Verst\u00e4ndnis der somato-sensorischen Ph\u00e4nomene und der Ver\u00e4nderungen in senso-motorischen Regelkreisen beim GTS f\u00fchren. <\/jats:p>","DOI":"10.1024\/1422-4917\/a000091","type":"journal-article","created":{"date-parts":[[2011,1,23]],"date-time":"2011-01-23T05:06:46Z","timestamp":1295759206000},"page":"161-169","source":"Crossref","is-referenced-by-count":6,"title":["Somato-sensorische Ph\u00e4nomene und die Rolle senso-motorischer Regelkreise beim Gilles de la Tourette Syndrom"],"prefix":"10.1024","volume":"39","author":[{"given":"Alexander","family":"M\u00fcnchau","sequence":"first","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Neurologie; Universit\u00e4tsklinikum Hamburg-Eppendorf, Hamburg"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00f6tz","family":"Thomalla","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Neurologie; Universit\u00e4tsklinikum Hamburg-Eppendorf, Hamburg"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veit","family":"Roessner","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Kinder- und Jugendpsychiatrie und -psychotherapie, Universit\u00e4t Dresden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"101","reference":[{"key":"c1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2003.tb00873.x"},{"key":"c2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1980.01780250029002"},{"key":"c3","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl050"},{"key":"c4","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3223(95)00101-8"},{"key":"c5","first-page":"199","volume":"70","author":"Chauvel P. 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