{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T17:45:05Z","timestamp":1792691105378,"version":"4.5.0"},"reference-count":48,"publisher":"Hogrefe Publishing Group","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Zeitschrift f\u00fcr Kinder- und Jugendpsychiatrie und Psychotherapie"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:p>Objective: Acute anorexia nervosa (AN) leads to reduced gray (GM) and white matter (WM) volume in the brain, which however improves again upon restoration of weight. Yet little is known about the extent and clinical correlates of these brain changes, nor do we know much about the time-course and completeness of their recovery. Methods: We conducted a meta-analysis and a qualitative review of all magnetic resonance imaging studies involving volume analyses of the brain in both acute and recovered AN. Results: We identified structural neuroimaging studies with a total of 214 acute AN patients and 177 weight-recovered AN patients. In acute AN, GM was reduced by 5.6% and WM by 3.8% compared to healthy controls (HC). Short-term weight recovery 2\u20135 months after admission resulted in restitution of about half of the GM aberrations and almost full WM recovery. After 2\u20138 years of remission GM and WM were nearly normalized, and differences to HC (GM: \u20131.0%, WM: \u20130.7%) were no longer significant, although small residual changes could not be ruled out. In the qualitative review some studies found GM volume loss to be associated with cognitive deficits and clinical prognosis. Conclusions: GM and WM were strongly reduced in acute AN. The completeness of brain volume rehabilitation remained equivocal.<\/jats:p>","DOI":"10.1024\/1422-4917\/a000265","type":"journal-article","created":{"date-parts":[[2013,12,23]],"date-time":"2013-12-23T23:07:41Z","timestamp":1387840061000},"page":"7-18","source":"Crossref","is-referenced-by-count":109,"title":["Morphological Changes in the Brain of Acutely Ill and Weight-Recovered Patients with Anorexia Nervosa"],"prefix":"10.1024","volume":"42","author":[{"given":"Jochen","family":"Seitz","sequence":"first","affiliation":[{"name":"Department of Child and Adolescent Psychiatry, Psychotherapy and Psychosomatics, University Hospital RWTH Aachen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"B\u00fchren","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Psychiatry, Psychotherapy and Psychosomatics, University Hospital RWTH Aachen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg 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