{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T17:15:48Z","timestamp":1715620548183},"reference-count":49,"publisher":"Hogrefe Publishing Group","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Zeitschrift f\u00fcr Kinder- und Jugendpsychiatrie und Psychotherapie"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:p> Fragestellung: H\u00e4matologische Ver\u00e4nderungen sind ein h\u00e4ufiges Ph\u00e4nomen der akuten Anorexia nervosa (AN). Dennoch ist der Zusammenhang mit klinischen Parametern noch unzureichend untersucht. Methodik: Bei 88 Patientinnen mit AN nach DSM-IV wurden bei station\u00e4rer Aufnahme und nach Gewichtsrehabilitation die Konzentration der Leukozyten, Erythrozyten und Thrombozyten, der H\u00e4moglobingehalt, der H\u00e4matokrit und ein Differenzialblutbild bestimmt und ein Zusammenhang mit verschiedenen klinischen Parametern untersucht. Ergebnisse: Bei Aufnahme zeigten sich milde Ver\u00e4nderungen der Blutwerte, die zumeist mit der Gewichtsrehabilitation reversibel waren. Patientinnen mit einem gro\u00dfen Gewichtsverlust vor Aufnahme und einem niedrigen altersadjustierten BMI sowie diejenigen, die Psychopharmaka einnahmen, hatten ein gr\u00f6\u00dferes Risiko, h\u00e4matologische Ver\u00e4nderungen aufzuweisen. Schlussfolgerungen: Auch wenn die h\u00e4matologischen Ver\u00e4nderungen bei jugendlichen Patientinnen mit AN zumeist milde sind, sollte bei Patientinnen mit niedrigem altersadjustiertem BMI und\/oder ausgepr\u00e4gter Gewichtsabnahme oder begleitenden Psychopharmakotherapie, auf ein sorgf\u00e4ltiges Monitoring des Blutbildes geachtet werden. Eine Ver\u00e4nderung der leukozytenabh\u00e4ngigen Immunantwort scheint bei erwachsenen chronifizierten Patientinnen zu einer gesteigerten Infektionsgefahr und damit einer erh\u00f6hten Mortalit\u00e4t beizutragen. <\/jats:p>","DOI":"10.1024\/1422-4917\/a000266","type":"journal-article","created":{"date-parts":[[2013,12,24]],"date-time":"2013-12-24T04:07:41Z","timestamp":1387858061000},"page":"19-26","source":"Crossref","is-referenced-by-count":5,"title":["H\u00e4matologische Ver\u00e4nderungen bei Anorexia nervosa im Kindes- und Jugendalter"],"prefix":"10.1024","volume":"42","author":[{"given":"Katharina","family":"B\u00fchren","sequence":"first","affiliation":[{"name":"Klinik f\u00fcr Psychiatrie, Psychosomatik und Psychotherapie des Kindes- und Jugendalters der Universit\u00e4tsklinik der RWTH Aachen, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"G\u00e4rtner","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Psychiatrie, Psychosomatik und Psychotherapie des Kindes- und Jugendalters der Universit\u00e4tsklinik der RWTH Aachen, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lieven N.","family":"Kennes","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Medizinische Statistik, RWTH Aachen University, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jochen","family":"Seitz","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Psychiatrie, Psychosomatik und Psychotherapie des Kindes- und Jugendalters der Universit\u00e4tsklinik der RWTH Aachen, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrich","family":"Hagenah","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Psychiatrie, Psychosomatik und Psychotherapie des Kindes- und Jugendalters der Universit\u00e4tsklinik der RWTH Aachen, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beate","family":"Herpertz-Dahlmann","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Psychiatrie, Psychosomatik und Psychotherapie des Kindes- und Jugendalters der Universit\u00e4tsklinik der RWTH Aachen, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"101","reference":[{"key":"c1","doi-asserted-by":"publisher","DOI":"10.1309\/2Y7X-YDXK-006B-XLT2"},{"key":"c2","volume-title":"Diagnostic and statistical manual of mental disorders \u2013 DSM-IV","author":"American Psychiatric Association","year":"1994","edition":"4"},{"key":"c3","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"c4","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2011.74"},{"key":"c5","doi-asserted-by":"publisher","DOI":"10.1024\/1661-8157\/a000145"},{"key":"c6","doi-asserted-by":"publisher","DOI":"10.1002\/eat.10189"},{"key":"c7","doi-asserted-by":"publisher","DOI":"10.1017\/CBO9781139150040"},{"key":"c8","doi-asserted-by":"publisher","DOI":"10.1002\/eat.20135"},{"key":"c9","doi-asserted-by":"publisher","DOI":"10.1007\/s00787-013-0376-z"},{"key":"c10","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2004.08.022"},{"key":"c11","unstructured":"CELL-DYN Sapphire\u0099 Bedienungsanleitung, 56\u20130302\/R1  (2005, Juni).\nAbbott Diagnostics Division."},{"key":"c12","doi-asserted-by":"publisher","DOI":"10.1080\/10640260903585540"},{"key":"c13","first-page":"791","volume":"86","author":"Devuyst O.","year":"1993","journal-title":"Quarterly Journal of Medicine"},{"key":"c14","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2013.12070868"},{"key":"c15","first-page":"401","volume":"162","author":"Gentile M. 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