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Methods: 69 patients and 63 age-matched healthy controls (HC) from 9 till 19 years of age were assessed using the Trail-Making Test (TMT) and self-report questionnaires. Results: In hierarchical regression analyses, set-shifting ability did not differ between AN and HC, whereas AN patients reported significantly higher rates of depression symptoms and OCD symptoms. Age significantly predicted set-shifting in the total sample. Only among AN patients aged 14 years and older did set-shifting decline with increasing age. Discussion: The presence of AN with depression or OCD symptoms or the duration of illness do not influence cognitive flexibility in children and adolescents. Early interventions may be helpful to prevent a decline in cognitive flexibility in adolescent AN with increasing age.<\/jats:p>","DOI":"10.1024\/1422-4917\/a000493","type":"journal-article","created":{"date-parts":[[2016,12,12]],"date-time":"2016-12-12T09:42:53Z","timestamp":1481535773000},"page":"371-380","source":"Crossref","is-referenced-by-count":19,"title":["Cognitive Flexibility in Juvenile Anorexia Nervosain Relation to Comorbid Symptoms of Depression, Obsessive Compulsive Symptoms and Duration of Illness"],"prefix":"10.1024","volume":"45","author":[{"given":"Anne","family":"R\u00f6\u00dfner","sequence":"first","affiliation":[{"name":"Charit\u00e9-Universit\u00e4tsmedizin Berlin, Department of Child and Adolescent Psychiatry, Psychosomatic Medicine and Psychotherapy"},{"name":"These authors contributed equally to this manuscript."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Izabela","family":"Juniak","sequence":"additional","affiliation":[{"name":"Charit\u00e9-Universit\u00e4tsmedizin Berlin, Department of Child and Adolescent Psychiatry, Psychosomatic Medicine and Psychotherapy"},{"name":"These authors contributed equally to this manuscript."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Betteke Maria","family":"van Noort","sequence":"additional","affiliation":[{"name":"These authors contributed equally to this manuscript."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernst","family":"Pfeiffer","sequence":"additional","affiliation":[{"name":"These authors contributed equally to this manuscript."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrike","family":"Lehmkuhl","sequence":"additional","affiliation":[{"name":"These authors contributed equally to this manuscript."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viola","family":"Kappel","sequence":"additional","affiliation":[{"name":"These authors contributed equally to this manuscript."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"101","reference":[{"key":"c1","first-page":"1","author":"Abbate-Daga G.","year":"2011","journal-title":"BioMed Central Psychiatry"},{"key":"c2","doi-asserted-by":"publisher","DOI":"10.2217\/phe.09.28"},{"key":"c3","author":"American Psychiatric Association.","year":"2003","journal-title":"Diagnostisches und Statistisches Manual Psychischer St\u00f6rungen \u2013 Textrevision DSM-IV-TR: \u00dcbersetzt nach der vierten Auflage des Diagnostic and Statistical Manual of Mental Disorders der American Psychiatric Association"},{"key":"c4","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1007\/s00787-011-0216-y","author":"Andres-Perpina S.","year":"2011","journal-title":"European Child & Adolescent Psychiatry"},{"key":"c5","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2011.74"},{"key":"c6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2012.02.041"},{"key":"c7","doi-asserted-by":"publisher","DOI":"10.3109\/10401230209147458"},{"key":"c8","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1007\/s00702-010-0567-4","author":"B\u00fchren K.","year":"2011","journal-title":"Journal of Neural Transmission"},{"key":"c9","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1007\/s00702-012-0821-z","author":"B\u00fchren K.","year":"2012","journal-title":"Journal of Neural Transmission"},{"key":"c10","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1024\/1422-4917.36.6.377","author":"B\u00fchren K.","year":"2008","journal-title":"Zeitschrift f\u00fcr Kinder- und Jugendpsychiatrie und Psychotherapie"},{"key":"c11","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1017\/S1355617708080727","author":"Burdick K. 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