{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T02:10:43Z","timestamp":1776996643555,"version":"3.51.4"},"reference-count":64,"publisher":"Hogrefe Publishing Group","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Zeitschrift f\u00fcr Kinder- und Jugendpsychiatrie und Psychotherapie"],"published-print":{"date-parts":[[2018,5,1]]},"abstract":"<jats:p>Zusammenfassung. Das Prader-Willi-Syndrom (PWS) geh\u00f6rt mit einer gesch\u00e4tzten Pr\u00e4valenzrate von 1\/15 000 bis 1\/30 000 aller Neugeborenen zu den h\u00e4ufigeren genetischen Syndromen beim Menschen. Urs\u00e4chlich kommt es dabei zur fehlenden Expression v\u00e4terlich gepr\u00e4gter Gene in der Region 15q11\u2013q13. Typische k\u00f6rperliche Symptome bei PWS sind muskul\u00e4re Hypotonie und F\u00fctterst\u00f6rungen im Neugeborenenalter, Hypogonadismus, Hyperphagie mit konsekutivem \u00dcbergewicht in der sp\u00e4teren Kindheit sowie Kleinwuchs. In der Mehrzahl aller F\u00e4lle liegt bei den Betroffenen eine leichte bis mittelgradige geistige Behinderung vor, dar\u00fcber hinaus sind Stimmungsschwankungen, heftige Wutausbr\u00fcche, Skin Picking und zwanghafte Verhaltensweisen typisch. Im Erwachsenenalter treten geh\u00e4uft psychotische St\u00f6rungen auf. Der Artikel gibt einen aktuellen \u00dcberblick \u00fcber \u00c4tiologie, k\u00f6rperliche Symptomatik, Entwicklungsaspekte, Verhaltensauff\u00e4lligkeiten und psychische St\u00f6rungen bei PWS. Au\u00dferdem wird der Kenntnisstand zu psychopharmakologischen bzw. psychotherapeutischen Interventionen dargestellt.<\/jats:p>","DOI":"10.1024\/1422-4917\/a000530","type":"journal-article","created":{"date-parts":[[2017,6,14]],"date-time":"2017-06-14T14:14:17Z","timestamp":1497449657000},"page":"238-246","source":"Crossref","is-referenced-by-count":2,"title":["Neuropsychiatrische Aspekte bei Prader-Willi-Syndrom \u2013 eine \u00dcbersicht"],"prefix":"10.1024","volume":"46","author":[{"given":"Wolfgang","family":"Briegel","sequence":"first","affiliation":[{"name":"Klinik f\u00fcr Kinder- und Jugendpsychiatrie, Psychosomatik und Psychotherapie, Leopoldina-Krankenhaus, Schweinfurt\/ Klinik und Poliklinik f\u00fcr Kinder- und Jugendpsychiatrie, Psychosomatik und Psychotherapie, Julius-Maximilians-Universit\u00e4t, W\u00fcrzburg"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"101","reference":[{"key":"c1","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1111\/j.1365-2788.1997.tb00713.x","author":"Akefeldt A.","year":"1997","journal-title":"Journal of Intellectual Disability Research"},{"key":"c2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"c3","doi-asserted-by":"publisher","DOI":"10.1007\/s40618-015-0312-9"},{"key":"c4","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.31824"},{"key":"c5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-200X.2009.02996.x"},{"key":"c6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2788.2010.01337.x"},{"key":"c7","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-2012"},{"key":"c8","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)07340-3"},{"key":"c9","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-015-2670-x"},{"key":"c10","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-009-9353-3"},{"key":"c11","first-page":"853","author":"Butler M. 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