{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T10:49:26Z","timestamp":1761648566316},"reference-count":51,"publisher":"Hogrefe Publishing Group","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Zeitschrift f\u00fcr Kinder- und Jugendpsychiatrie und Psychotherapie"],"published-print":{"date-parts":[[2019,3,1]]},"abstract":"<jats:p>Zusammenfassung. Obwohl insgesamt selten (\u201eorphan disease\u201c mit einer Inzidenz von 1:6000), ist die Tuber\u00f6se Sklerose (TSC) eine der h\u00e4ufigsten monogenetisch bedingten Erkrankungen mit Bedeutung f\u00fcr die Kinder- und Jugendpsychiatrie. TSC f\u00fchrt bei bis zu 90 % der Betroffenen zu neurologischen St\u00f6rungen wie Epilepsie und ebenfalls bei bis zu 90 % zu psychiatrischen Manifestationen wie Autismus-Spektrum-St\u00f6rungen, Aufmerksamkeitsdefizit-\/Hyperaktivit\u00e4tsst\u00f6rung, affektiven St\u00f6rungen und Intelligenzminderung. In den letzten Jahren wurden sowohl zum Verst\u00e4ndnis des molekularen Pathomechanismus der Erkrankung als auch zu Diagnostik und Behandlung erhebliche Fortschritte erzielt. Die vorliegende \u00dcbersichtsarbeit stellt diese aktuellen Entwicklungen dar. Im ersten Abschnitt zeigen wir den Bedarf an psychiatrischer Diagnostik und Begleitung von Patienten mit TSC auf und behandeln Herausforderungen und Schwierigkeiten in der interdisziplin\u00e4ren Zusammenarbeit zwischen Kinder- und Jugendpsychiatrie, Neurop\u00e4diatrie und anderen Berufsgruppen. Im zweiten Teil stellen wir das Konzept der TSC-assoziierten neuropsychiatrischen St\u00f6rungen (TAND) vor, das von einer internationalen Expertengruppe entwickelt wurde, um Kliniker, Familien und Betroffene in der Diagnostik und Behandlung psychiatrischer Symptome und St\u00f6rungen zu unterst\u00fctzen, sowie ein neuartiges Screeninginstrument (TAND-Checkliste). Schlie\u00dflich geben wir einen \u00dcberblick \u00fcber k\u00fcrzlich publizierte Studien bez\u00fcglich m\u00f6glicher Krankheitsmodifikation der neuropsychiatrischen Manifestationen mittels mTOR-Inhibitoren. Die deutsche \u00dcbersetzung der TAND-Checkliste ist dem Artikel als elektronisches Supplement (ESM) beigef\u00fcgt.<\/jats:p>","DOI":"10.1024\/1422-4917\/a000604","type":"journal-article","created":{"date-parts":[[2018,8,6]],"date-time":"2018-08-06T14:12:05Z","timestamp":1533564725000},"page":"139-153","source":"Crossref","is-referenced-by-count":2,"title":["Neuropsychiatrische Manifestationen bei Tuber\u00f6ser Sklerose (TSC): Diagnostische Leitlinien, TAND-Konzept und Therapie mit mTOR-Inhibitoren"],"prefix":"10.1024","volume":"47","author":[{"given":"Robert","family":"Waltereit","sequence":"first","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Kinder- und Jugendpsychiatrie und -psychotherapie, Technische Universit\u00e4t Dresden, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martha","family":"Feucht","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinik f\u00fcr Kinder- und Jugendheilkunde, Medizinische Universit\u00e4t Wien, \u00d6sterreich"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magdalena C.","family":"de Vries","sequence":"additional","affiliation":[{"name":"Abteilung f\u00fcr Kinder- und Jugendpsychiatrie, Universit\u00e4t Kapstadt, S\u00fcdafrika"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Huemer","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinik f\u00fcr Kinder- und Jugendpsychiatrie, Medizinische Universit\u00e4t Wien, \u00d6sterreich"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veit","family":"Roessner","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Kinder- und Jugendpsychiatrie und -psychotherapie, Technische Universit\u00e4t Dresden, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petrus J.","family":"de Vries","sequence":"additional","affiliation":[{"name":"Abteilung f\u00fcr Kinder- und Jugendpsychiatrie, Universit\u00e4t Kapstadt, S\u00fcdafrika"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"101","reference":[{"key":"c1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69041-7"},{"key":"c2","doi-asserted-by":"publisher","DOI":"10.1111\/epi.13766"},{"key":"c3","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61767-X"},{"key":"c4","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awf124"},{"key":"c5","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2017.02.007"},{"issue":"7","key":"c6","first-page":"733","volume":"14","author":"Curatolo P.","year":"2015","journal-title":"Neurology"},{"key":"c7","doi-asserted-by":"publisher","DOI":"10.1111\/jir.12057"},{"key":"c8","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-11-0445"},{"key":"c9","doi-asserted-by":"publisher","DOI":"10.1002\/9783527630073.ch12"},{"key":"c10","doi-asserted-by":"publisher","DOI":"10.1016\/j.nurt.2010.05.001"},{"key":"c11","doi-asserted-by":"crossref","unstructured":"de Vries, P. 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