{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,26]],"date-time":"2025-07-26T09:26:23Z","timestamp":1753521983710},"reference-count":71,"publisher":"Hogrefe Publishing Group","issue":"3","license":[{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Zeitschrift f\u00fcr Kinder- und Jugendpsychiatrie und Psychotherapie"],"published-print":{"date-parts":[[2022,5,1]]},"abstract":"<jats:p>Zusammenfassung. Genetische Varianten beeinflussen die Gewichtsregulation und die Entwicklung von Essst\u00f6rungen. Zun\u00e4chst haben familienbasierte, sogenannte formalgenetische Studien den erblichen Anteil an der Gewichtsregulation und an der \u00c4tiologie von Essst\u00f6rungen beleuchtet. In einer Vielzahl von Studien zeigten sich sowohl f\u00fcr die Varianz des K\u00f6rpergewichts als auch f\u00fcr die Entstehung von Essst\u00f6rungen Erblichkeitssch\u00e4tzer (Heritabilit\u00e4tsraten) von \u00fcber 50 %. Mit diesem Wissen begab man sich in den 90er-Jahren des letzten Jahrhunderts auf die Suche nach den zugrundeliegenden Genen (genauer: genetischen Varianten), die das K\u00f6rpergewicht, das Essverhalten oder beide Ph\u00e4notypen auf Grundlage geteilter Mechanismen beeinflussen. Zun\u00e4chst wurden Kandidatengenstudien durchgef\u00fchrt. Dabei untersuchte man auf Grundlage unterschiedlicher, v. a. aber pathophysiologisch plausibler \u00dcberlegungen Gene mit hoher Relevanz f\u00fcr die untersuchten Ph\u00e4notypen. Dieser Ansatz war f\u00fcr Essst\u00f6rungen nicht sehr erfolgreich, f\u00fcr die Gewichtsregulation konnte eine Handvoll Gene identifiziert werden. Verbunden mit gro\u00dfen methodischen Fortschritten in der genetischen Forschung und v. a. der Etablierung sogenannter genomweiter Assoziationsstudien (GWAS) Anfang der 2000er-Jahre konnten bislang \u00fcber 1000 Varianten\/Genorte detektiert werden, die das K\u00f6rpergewicht beeinflussen. F\u00fcr die Essst\u00f6rung Anorexia nervosa (AN) sind aktuell acht solcher Genorte beschrieben. Diese Ergebnisse, aber auch aktuelle Ans\u00e4tze zu ph\u00e4notyp\u00fcbergreifenden Analysen lassen Einblicke in die komplexe Regulation des K\u00f6rpergewichtes zu und haben zudem unerwartete Pathomechanismen f\u00fcr AN aufgezeigt.<\/jats:p>","DOI":"10.1024\/1422-4917\/a000829","type":"journal-article","created":{"date-parts":[[2021,7,30]],"date-time":"2021-07-30T13:12:55Z","timestamp":1627650775000},"page":"175-185","source":"Crossref","is-referenced-by-count":5,"title":["Ebenen der genetischen Analyse komplexer Ph\u00e4notypen am Beispiel der Anorexia nervosa und der Varianz des K\u00f6rpergewichts"],"prefix":"10.1024","volume":"50","author":[{"given":"Raphael","family":"Hirtz","sequence":"first","affiliation":[{"name":"Klinik f\u00fcr Psychiatrie, Psychosomatik und Psychotherapie des Kindes- und Jugendalters, LVR-Klinikum Essen, Kliniken und Institut der Universit\u00e4t Duisburg-Essen, Universit\u00e4tsklinikum Essen, Deutschland"},{"name":"Abteilung f\u00fcr P\u00e4diatrische Endokrinologie und Diabetologie, Kinderklinik II, Universit\u00e4tsklinikum Essen, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiran","family":"Zheng","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Psychiatrie, Psychosomatik und Psychotherapie des Kindes- und Jugendalters, LVR-Klinikum Essen, Kliniken und Institut der Universit\u00e4t Duisburg-Essen, Universit\u00e4tsklinikum Essen, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luisa S.","family":"Rajcsanyi","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Psychiatrie, Psychosomatik und Psychotherapie des Kindes- und Jugendalters, LVR-Klinikum Essen, Kliniken und Institut der Universit\u00e4t Duisburg-Essen, Universit\u00e4tsklinikum Essen, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"Libuda","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Psychiatrie, Psychosomatik und Psychotherapie des Kindes- und Jugendalters, LVR-Klinikum Essen, Kliniken und Institut der Universit\u00e4t Duisburg-Essen, Universit\u00e4tsklinikum Essen, Deutschland"},{"name":"Institut f\u00fcr Ern\u00e4hrung, Konsum und Gesundheit, Fakult\u00e4t f\u00fcr Naturwissenschaften, Universit\u00e4t Paderborn, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jochen","family":"Antel","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Psychiatrie, Psychosomatik und Psychotherapie des Kindes- und Jugendalters, LVR-Klinikum Essen, Kliniken und Institut der Universit\u00e4t Duisburg-Essen, Universit\u00e4tsklinikum Essen, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Triinu","family":"Peters","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Psychiatrie, Psychosomatik und Psychotherapie des Kindes- und Jugendalters, LVR-Klinikum Essen, Kliniken und Institut der Universit\u00e4t Duisburg-Essen, Universit\u00e4tsklinikum Essen, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes","family":"Hebebrand","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Psychiatrie, Psychosomatik und Psychotherapie des Kindes- und Jugendalters, LVR-Klinikum Essen, Kliniken und Institut der Universit\u00e4t Duisburg-Essen, Universit\u00e4tsklinikum Essen, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anke","family":"Hinney","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Psychiatrie, Psychosomatik und Psychotherapie des Kindes- und Jugendalters, LVR-Klinikum Essen, Kliniken und Institut der Universit\u00e4t Duisburg-Essen, Universit\u00e4tsklinikum Essen, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"101","reference":[{"key":"c1","doi-asserted-by":"publisher","DOI":"10.1097\/GIM.0b013e3181ef4286"},{"key":"c2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2019.19080825"},{"key":"c3","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2013.187"},{"key":"c4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1993.tb18834.x"},{"key":"c5","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2247"},{"key":"c6","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X16666180222163450"},{"key":"c7","doi-asserted-by":"publisher","DOI":"10.1016\/j.psc.2018.10.007"},{"key":"c8","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3406"},{"key":"c9","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-7717-8_6"},{"key":"c10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2019.01.021"},{"key":"c11","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4000771"},{"key":"c12","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-14-0480"},{"key":"c13","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddv472"},{"key":"c14","first-page":"8","author":"Fullerton J. 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