{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T05:48:32Z","timestamp":1777614512226,"version":"3.51.4"},"reference-count":75,"publisher":"Hogrefe Publishing Group","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Zeitschrift f\u00fcr Kinder- und Jugendpsychiatrie und Psychotherapie"],"published-print":{"date-parts":[[2022,5,1]]},"abstract":"<jats:p> Zusammenfassung. Die vielseitigen Wechselwirkungen des Darmmikrobioms mit dem Stoffwechsel, dem Immunsystem und dem Gehirn des Wirtes werden zunehmend zu einem relevanten Forschungsschwerpunkt. Studien legen einen Zusammenhang zwischen einem ver\u00e4nderten Darmmikrobiom und sowohl somatischen Erkrankungen wie Colitis ulcerosa, Morbus Crohn und Diabetes als auch psychischen Erkrankungen wie \u00c4ngsten und Depression nahe. Auch Patient_innen mit Anorexia nervosa (AN) zeigen deutliche Ver\u00e4nderungen des Darmmikrobioms. Diese Ver\u00e4nderungen scheinen unter anderem mit einer abweichenden Energieaufnahme aus der Nahrung, immunologischen und entz\u00fcndlichen Prozessen, genetischer Pr\u00e4disposition, hormonellen Ver\u00e4nderungen und einer m\u00f6glicherweise erh\u00f6hten Darmpermeabilit\u00e4t assoziiert zu sein. Transplantation von Stuhl von Patient_innen mit AN in Ratten f\u00fchrte zu einer Appetitminderung und Gewichtsreduktion sowie \u00e4ngstlichem und zwanghaftem Verhalten. In dieser \u00dcbersichtsarbeit fassen wir m\u00f6gliche Mechanismen der Interaktion zwischen dem Darmmikrobiom und dem Wirt zusammen und stellen erste Befunde zum Mikrobiom bei AN vor. Forschung zu Ern\u00e4hrungsinterventionen zum Beispiel mit Pr\u00e4- und Probiotika oder Nahrungssupplementen wie Omega-3 Fetts\u00e4uren, die darauf abzielen, das Darmmikrobiom positiv zu beeinflussen, k\u00f6nnte zu zus\u00e4tzlichen Behandlungsm\u00f6glichkeiten in der Therapie von Patient_innen mit AN f\u00fchren. <\/jats:p>","DOI":"10.1024\/1422-4917\/a000830","type":"journal-article","created":{"date-parts":[[2021,10,20]],"date-time":"2021-10-20T10:02:36Z","timestamp":1634724156000},"page":"227-237","source":"Crossref","is-referenced-by-count":4,"title":["Das Darmmikrobiom und seine klinischen Implikationen im Kontext der                     Anorexia nervosa"],"prefix":"10.1024","volume":"50","author":[{"given":"Stefanie","family":"Trinh","sequence":"first","affiliation":[{"name":"Institut f\u00fcr Neuroanatomie, Uniklinik                     RWTH Aachen, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lara","family":"Keller","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Psychiatrie, Psychosomatik                     und Psychotherapie des Kindes- und Jugendalters, Uniklinik RWTH Aachen,                         Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jochen","family":"Seitz","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Psychiatrie, Psychosomatik                     und Psychotherapie des Kindes- und Jugendalters, Uniklinik RWTH Aachen,                         Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"101","reference":[{"key":"c1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwy257"},{"key":"c2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.32567"},{"key":"c3","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-0965-1"},{"key":"c4","first-page":"205","volume":"12","author":"Ananthakrishnan A. 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