{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T02:49:57Z","timestamp":1789094997243,"version":"build-2803163510"},"reference-count":58,"publisher":"Hogrefe Publishing Group","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Zeitschrift f\u00fcr Kinder- und Jugendpsychiatrie und Psychotherapie"],"abstract":"<jats:p> Zusammenfassung: In den vergangenen Jahren ist ein deutlich zunehmendes Interesse an Darmmikrobiota und deren Interaktion mit dem Gehirn (Darm-Gehirn-Achse) zu beobachten. Dabei sind die bisher gewonnen Erkenntnisse der Mikrobiomforschung nicht nur f\u00fcr Grundlagenwissenschaftler_innen interessant, sondern bieten ebenfalls relevante Einsichten f\u00fcr die klinische Praxis. So erscheint ein kausaler Zusammenhang zwischen dem Darmmikrobiom und verschiedenen somatischen Erkrankungen wie Diabetes mellitus, chronisch entz\u00fcndlichen Darmerkrankungen oder Adipositas, aber auch psychiatrischen Erkrankungen wie Depressionen, Angstst\u00f6rungen oder Essst\u00f6rungen plausibel. Um den kausalen Zusammenhang der Darmbakterien mit einzelnen Ph\u00e4notypen in Verbindung zu bringen, werden sogenannte Stuhltransplantationen (f\u00e4kale Mikrobiotatransplantationen) im pr\u00e4klinischen Kontext angewandt. Hierzu werden Mikrobiotaproben von Patient_innen in Versuchstiere transferiert, um m\u00f6gliche Ver\u00e4nderungen des Ph\u00e4notyps zu beobachten. Im klinischen Kontext werden f\u00e4kale Mikrobiotatransplantationen f\u00fcr erste Erkrankungen, zum Beispiel bei wiederkehrenden Infektionen mit Clostridioides difficile oder bei chronisch entz\u00fcndlichen Darmerkrankungen bereits in der Therapie eingesetzt und sind bei ersterer bereits Teil der offiziellen Behandlungsleitlinien. F\u00fcr viele weitere Erkrankungen, darunter auch psychische Erkrankungen, werden die M\u00f6glichkeiten der Anwendung von Stuhltransplantationen im Rahmen der Therapie derzeit verst\u00e4rkt erforscht. Bisherige Erkenntnisse deuten darauf hin, dass das Darmmikrobiom und insbesondere f\u00e4kale Mikrobiotatransplantationen ein vielversprechender Ansatzpunkt f\u00fcr neue Therapien darstellt. <\/jats:p>","DOI":"10.1024\/1422-4917\/a000928","type":"journal-article","created":{"date-parts":[[2023,3,9]],"date-time":"2023-03-09T14:07:48Z","timestamp":1678370868000},"source":"Crossref","is-referenced-by-count":2,"title":["F\u00e4kale Mikrobiotatransplantationen im Zusammenhang mit (kinder-                     und jugend-)psychiatrischen Erkrankungen"],"prefix":"10.1024","author":[{"given":"Stefanie","family":"Trinh","sequence":"first","affiliation":[{"name":"Institut f\u00fcr Neuroanatomie, Uniklinik                     RWTH Aachen, Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9714-067X","authenticated-orcid":true,"given":"Lara","family":"Keller","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Psychiatrie, Psychosomatik                     und Psychotherapie des Kindes- und Jugendalters, Uniklinik RWTH Aachen,                         Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beate","family":"Herpertz-Dahlmann","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Psychiatrie, Psychosomatik                     und Psychotherapie des Kindes- und Jugendalters, Uniklinik RWTH Aachen,                         Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0110-7980","authenticated-orcid":true,"given":"Jochen","family":"Seitz","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Psychiatrie, Psychosomatik                     und Psychotherapie des Kindes- und Jugendalters, Uniklinik RWTH Aachen,                         Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"101","published-online":{"date-parts":[[2023,3,9]]},"reference":[{"key":"c1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-0965-1"},{"key":"c2","first-page":"205","volume":"12","author":"Ananthakrishnan A. 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