{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T16:59:16Z","timestamp":1694624356331},"reference-count":50,"publisher":"Hogrefe Publishing Group","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Zeitschrift f\u00fcr Kinder- und Jugendpsychiatrie und Psychotherapie"],"published-print":{"date-parts":[[2005,7]]},"abstract":"<jats:p> Zusammenfassung: Fragestellung: Wegen ihres besonderen Rezeptorbindungsprofils beeinflussen atypische Neuroleptika neben Produktiv- auch Minussymptome g\u00fcnstig. Insbesondere die Affinit\u00e4t zum serotonergen System legt eine Wirksamkeit auch bei zwanghaften, \u00e4ngstlichen oder depressiven Symptomen nahe. Im Weiteren soll der aktuelle Stand der klinischen Erfahrungen sowie die derzeitige Studienlage zu atypischen Neuroleptika und deren Einsatz bei verschiedenen Indikationen au\u00dferhalb der Schizophrenie in der Kinder- und Jugendpsychiatrie referiert werden. Methodik: Die bisherige Studienlage wurde f\u00fcr die Jahre 1988 bis 2004 mittels PubMed und CurrentContents ermittelt. Ergebnisse: Anwendungsbereiche f\u00fcr atypische Neuroleptika sind neben Erkrankungen aus dem schizophrenen Formenkreis Ticst\u00f6rungen, manische und bipolare St\u00f6rungen, Impulskontrollst\u00f6rungen, (Auto-)Aggressivit\u00e4t sowie Anorexia nervosa. Problematisch sind die l\u00fcckenhafte Studienlage f\u00fcr das Kindes- und Jugendalter mit Fehlen von Placebo-kontrollierten Doppelblindstudien bzw. offenen Studien an gr\u00f6\u00dferen Populationen sowie die Off-label-Anwendung. Schlussfolgerungen: Atypische Neuroleptika sind aufgrund ihrer relativ guten Vertr\u00e4glichkeit Teil des Therapiestandards in der Kinder- und Jugendpsychiatrie geworden. Sie erweisen sich als wirksam bei Schizophrenien, Tics, Manien und bipolaren affektiven St\u00f6rungen, Impulsivit\u00e4t, (Auto-)Aggressivit\u00e4t sowie therapieresistenten Essst\u00f6rungen. <\/jats:p>","DOI":"10.1024\/1422-4917.33.3.159","type":"journal-article","created":{"date-parts":[[2005,7,6]],"date-time":"2005-07-06T23:33:22Z","timestamp":1120692802000},"page":"159-168","source":"Crossref","is-referenced-by-count":2,"title":["Atypische Neuroleptika in der kinder- und jugendpsychiatrischen Behandlung - Indikationen au\u00dferhalb der Schizophrenie mit Anwendungshinweisen"],"prefix":"10.1024","volume":"33","author":[{"given":"Claudia","family":"Mehler-Wex","sequence":"first","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Kinder- und Jugendpsychiatrie und Psychotherapie der Universit\u00e4t W\u00fcrzburg (\u00c4rztlicher Direktor: Prof. Dr. A. 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