{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T03:45:33Z","timestamp":1792295133949,"version":"4.4.0"},"reference-count":93,"publisher":"Hogrefe Publishing Group","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Zeitschrift f\u00fcr Kinder- und Jugendpsychiatrie und Psychotherapie"],"published-print":{"date-parts":[[2006,11]]},"abstract":"<jats:p> Zusammenfassung: Die Lese-Rechtschreibst\u00f6rung (LRS) ist eine der h\u00e4ufigsten Entwicklungsst\u00f6rungen. Die Ursachen dieser komplexen St\u00f6rung sind bisher nur kaum verstanden. Familienuntersuchungen zeigen, dass die LRS famili\u00e4r geh\u00e4uft auftritt und dass das Risiko f\u00fcr ein Geschwisterkind, eine LRS zu entwickeln, ca. 3,5fach erh\u00f6ht ist. Verschiedene kognitive F\u00e4higkeiten sind mit der LRS korreliert. Hierzu geh\u00f6ren die phonologische Bewusstheit, orthographisches Wissen, phonologisches Dekodieren, auditives Kurzzeitged\u00e4chtnis und schnelles Benennen. Eine famili\u00e4re H\u00e4ufung dieser mit der LRS korrelierten Dimensionen und eine hohe Erblichkeit (Heritabilit\u00e4t) wurden wiederholt gefunden. Die Heritabilit\u00e4t f\u00fcr die Lesef\u00e4higkeit liegt zwischen 50-60%, f\u00fcr die Rechtschreibst\u00f6rung zwischen 50 und 70%. Durch genomweite Kopplungsuntersuchungen wurden bisher 9 Kandidatengenregionen (DYX1-9) identifiziert. Vier Kandidatengene, DCDC2, KIAA0319, ROBO1 und DYX1C1 wurden k\u00fcrzlich beschrieben. Diese beeinflussen die neuronale Migration und sind daher funktionell aussichtsreiche Kandidatengene f\u00fcr die LRS. Allerdings konnte bisher keine funktionell relevante Mutation gefunden werden. Die Komorbidit\u00e4t zwischen LRS und ADHD sowie LRS und Sprachentwicklungsst\u00f6rungen k\u00f6nnte zum Teil durch gemeinsame genetische Faktoren erkl\u00e4rt werden. In der Zukunft wird es f\u00fcr die Ursachenforschung der LRS entscheidend sein, m\u00f6glichst alle ursachenrelevanten Dimensionen gemeinsam an ausreichend gro\u00dfen Stichproben zu untersuchen. Neben den relevanten neurobiologischen Faktoren sollten auch Umweltfaktoren und die verschiedenen Interaktionen, wie z.B. Gen-Umwelt und Gen-Gen-Interaktionen untersucht werden. In einem europ\u00e4ischen, kollaborativen Forschungsvorhaben (NeuroDys) wird weltweit die gr\u00f6\u00dfte Stichprobe von Kindern mit einer LRS gesammelt und untersucht, um durch ein verbessertes Ursachenverst\u00e4ndnis unter Einschluss der Identifikation von genetischen Risikofaktoren die Komplexit\u00e4t des St\u00f6rungsbildes besser zu verstehen und perspektivisch spezifische Therapien zu entwickeln. <\/jats:p>","DOI":"10.1024\/1422-4917.34.6.435","type":"journal-article","created":{"date-parts":[[2006,11,7]],"date-time":"2006-11-07T22:55:11Z","timestamp":1162940111000},"page":"435-444","source":"Crossref","is-referenced-by-count":21,"title":["Zur Genetik der Lese-Rechtschreibschw\u00e4che"],"prefix":"10.1024","volume":"34","author":[{"given":"Gerd","family":"Schulte-K\u00f6rne","sequence":"first","affiliation":[{"name":"Klinik f\u00fcr Kinder- und Jugendpsychiatrie, Psychosomatik und Psychotherapie, Klinikum der Universit\u00e4t M\u00fcnchen1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Warnke","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Kinder- und Jugendpsychiatrie und Psychotherapie, Universit\u00e4tsklinikum W\u00fcrzburg2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helmut","family":"Remschmidt","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Kinder- und Jugendpsychiatrie und -psychotherapie, Universit\u00e4tsklinikum Gie\u00dfen-Marburg, Standort Marburg, Philipps-Universit\u00e4t Marburg3"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"101","reference":[{"key":"c1","doi-asserted-by":"publisher","DOI":"10.1086\/426154"},{"key":"c2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2004.08.019"},{"key":"c3","doi-asserted-by":"publisher","DOI":"10.1086\/375143"},{"key":"c4","doi-asserted-by":"publisher","DOI":"10.1086\/341095"},{"key":"c5","doi-asserted-by":"publisher","DOI":"10.1044\/jslhr.4201.155"},{"key":"c6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7610.1996.tb01420.x"},{"key":"c7","doi-asserted-by":"publisher","DOI":"10.1037\/0033-2909.130.6.858"},{"key":"c8","doi-asserted-by":"publisher","DOI":"10.1007\/s11881-002-0006-9"},{"key":"c9","doi-asserted-by":"publisher","DOI":"10.1126\/science.7939663"},{"key":"c10","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.14.1740"},{"key":"c11","doi-asserted-by":"publisher","DOI":"10.1044\/1092-4388(2005\/096)"},{"key":"c12","doi-asserted-by":"publisher","DOI":"10.1044\/1092-4388(2002\/093)"},{"key":"c13","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.30018"},{"key":"c14","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.20068"},{"key":"c15","first-page":"539","volume-title":"American Journal of Medical Genetics","volume":"105","author":"Collaborative Linkage Study of Autism","year":"2001"},{"key":"c16","first-page":"625","volume-title":"Behavior Genetics","volume":"31","author":"Davies C. 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