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F\u00fcr die Entstehung dieser Erkrankungen spielen genetische Faktoren eine entscheidende Rolle. Familien- und Zwillingsstudien konnten das erh\u00f6hte Erkrankungsrisiko von Kindern in betroffenen Familien und die hohe Heritabilit\u00e4t, insbesondere von bipolaren St\u00f6rungen, eindr\u00fccklich nachweisen. Die Suche nach pr\u00e4disponierenden Krankheitsgenen mittels Kopplungs- und Assoziationsanalysen konnte in den vergangenen Jahren beachtliche Fortschritte erzielen. Insbesondere das s-Allel des Serotonintransportergens wurde wiederholt als Risikofaktor best\u00e4tigt. Meta-Analysen deuten allerdings auf relativ begrenzte Effekte einzelner Gene hin. Neben genetischen Komponenten sind Umweltfaktoren ma\u00dfgeblich an der Krankheitsgenese beteiligt: Bei unipolaren Depressionen wird die Erkrankungswahrscheinlichkeit bei entsprechender genetischer Disposition wesentlich durch protektive oder pathogene Umweltfaktoren im Sinne einer engen Gen-Umwelt-Interaktion moduliert. <\/jats:p>","DOI":"10.1024\/1422-4917.36.1.27","type":"journal-article","created":{"date-parts":[[2008,1,28]],"date-time":"2008-01-28T21:41:39Z","timestamp":1201556499000},"page":"27-43","source":"Crossref","is-referenced-by-count":22,"title":["Genetik depressiver St\u00f6rungen"],"prefix":"10.1024","volume":"36","author":[{"given":"Gerd","family":"Schulte-K\u00f6rne","sequence":"first","affiliation":[{"name":"Klinik f\u00fcr Kinder- und Jugendpsychiatrie, Psychosomatik und Psychotherapie, Klinikum der Universit\u00e4t M\u00fcnchen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antje-Kathrin","family":"Allgaier","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Kinder- und Jugendpsychiatrie, Psychosomatik und Psychotherapie, Klinikum der Universit\u00e4t M\u00fcnchen"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"101","reference":[{"key":"c1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbl028"},{"key":"c2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0047.2004.00325.x"},{"key":"c3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2005.00268.x"},{"key":"c4","doi-asserted-by":"publisher","DOI":"10.1017\/S003329179700593X"},{"key":"c5","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-88741-3"},{"key":"c6","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(02)36037-0"},{"key":"c7","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001012"},{"key":"c8","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2003.12.008"},{"key":"c9","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-199611000-00011"},{"key":"c10","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0327(93)90060-W"},{"key":"c11","author":"Brown G. 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