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Methodik: Durchgef\u00fchrt wurde eine Medline-Recherche (Pubmed), mit der Suchstrategie: bipolar - mania - adolescents - early onset - pediatric onset - randomized - controlled trial - neuroleptics - antipsychotics - lithium - moodstabilizer. Ergebnisse: Trotz weit verbreiteter Anwendung von f\u00fcr das Erwachsenenalter etablierten Substanzen bei bipolar erkrankten Kindern und Jugendlichen existiert aktuell eine nur unzureichende Datenlage zur Wirksamkeit und Sicherheit der Anwendung in dieser Altersgruppe. Die Interpretation der Datenlage aus \u00fcberwiegend offenen Studien wird durch die Kontroverse bez\u00fcglich der diagnostischen Validit\u00e4t bipolarer St\u00f6rungen bei Kindern erschwert. Nebenwirkungen treten bei Kindern und Jugendlichen unter allen eingesetzten Substanzen h\u00e4ufiger und ausgepr\u00e4gter auf als bei Erwachsenen und limitieren den Einsatz. 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